A novel computerized functional assessment for human immunodeficiency virus-associated neurocognitive disorder.
A novel computerized functional assessment for human immunodeficiency virus-associated neurocognitive disorder.
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DOI：
10.1007/s13365-013-0195-5
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发表时间：
2013-10
影响因子：
3.2
通讯作者：
Sacktor, Ned
中科院分区：
文献类型：
--
作者：
Rosenthal, Liana S.;Skolasky, Richard L.;Moxley, Richard T.;Roosa, Heidi Vornbrock;Selnes, Ola A.;Eschman, Amy;McArthur, Justin C.;Sacktor, Ned
关键词：
人类免疫缺陷病毒（HIV）相关的神经认知障碍（HAND）存在于30 - 60%的HIV阳性（HIV+）个体中，可以通过神经心理测试和功能损害水平来评估。因此，HAND的诊断需要对功能损伤进行准确的评估。轻度认知障碍计算机评估（CAMCI）是一种基于计算机的筛查工具，包括基于性能的功能障碍测量。我们试图评估CAMCI作为HAND的功能评估工具。114名HIV阳性患者和38名HIV阴性（HIV -）患者接受了神经心理学和CAMCI测试。使用Frascati标准对HIV+受试者的认知状态进行分类。按照认知障碍分类的HIV阳性受试者在CAMCI的几个任务上比HIV阳性受试者表现更差，包括去超市的方向（p = 0.05, p = 0.03），回忆要买的东西（p = 0.01, p = 0.02），记住在超市（p < 0.01, p = 0.01）和邮局（p < 0.01, p = 0.03）停下来。在控制了丙型肝炎状态和抑郁症状后，“跟随超市指示”和“召回购买的物品”任务不再显著。“记住同时做两件事”的任务仍然具有显著性（p < 0.01）。因此，CAMCI任务的一个子集成功地将HIV+患者与HIV -个体区分开来。丙型肝炎状态和抑郁症状的差异可以解释CAMCI中功能评估的一些差异。这些结果表明，CAMCI可能是一种有用的、客观的、基于性能的HIV患者功能评估。本文的在线版本（doi:10.1007/s13365-013-0195-5）包含补充材料，仅供授权用户使用。
Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) is present in 30–60 % of HIV-positive (HIV+) individuals and can be assessed by neuropsychological testing and level of functional impairment. HAND diagnosis therefore requires accurate assessment of functional impairment. The Computer Assessment of Mild Cognitive Impairment (CAMCI) is a computer-based screening tool that includes performance-based measures of functional impairment. We sought to evaluate the CAMCI as a functional assessment tool in HAND. One hundred fourteen HIV+ patients and 38 HIV-negative (HIV−) patients underwent neuropsychological and CAMCI testing. Cognitive status for HIV+ subjects was classified using the Frascati criteria. HIV+ subjects grouped together and classified by cognitive impairment performed worse than HIV− subjects on several of the CAMCI tasks, including following directions to the supermarket (p = 0.05, p = 0.03), recalling which items to purchase (p = 0.01, p = 0.02), and remembering to stop at a supermarket (p < 0.01, p = 0.01) and the post office (p < 0.01, p = 0.03). After controlling for hepatitis C status and depression symptomatology, the tasks “following directions to the supermarket” and the “recalling which items to purchase” were no longer significant. The “remembering to run two separate errands” tasks retained their significance (p < 0.01 for both tasks). A subset of the CAMCI tasks therefore successfully differentiated HIV+ patients from HIV− individuals. Differences in hepatitis C status and depression symptomatology could account for some of the function assessment differences in the CAMCI. These results suggest the CAMCI could be a useful objective performance-based functional assessment in patients with HIV. The online version of this article (doi:10.1007/s13365-013-0195-5) contains supplementary material, which is available to authorized users.
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DOI：
10.1017/s1355617704102130
发表时间：
2004-05-01
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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发表时间：
2006-10-01
影响因子：
2.2
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影响因子：
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