Predictive diagnostic and/or prognostic biomarkers obtained from routine blood biochemistry in patients with solitary intracranial tumor.
Predictive diagnostic and/or prognostic biomarkers obtained from routine blood biochemistry in patients with solitary intracranial tumor.
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孤立颅内肿瘤患者从常规血液生物化学获得的预测性诊断和/或预后生物标志物。
DOI：
10.5937/jomb0-24722
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发表时间：
2021-01-26
影响因子：
2.5
通讯作者：
Bakar B
中科院分区：
文献类型：
--
作者：
Yuksel U;Ogden M;Ozdemir A;Kisa U;Bakar B
放射学和/或实验室检查有时可能不足以区分胶质母细胞瘤和转移性脑肿瘤。本研究的目的是寻找可能的预测性生物标志物，这些生物标志物来自术前评估的每个孤立性脑肿瘤患者的常规血液生化分析结果，以区分胶质母细胞瘤和转移性脑肿瘤，并揭示短期预后。本研究纳入2015年1月至2018年9月在神经外科门诊就诊的患者，分为胶质瘤组（n=12）和转移组（n=17）。患者资料包括年龄、性别、格拉斯哥昏迷量表评分、住院时间、格拉斯哥预后量表（GOS）评分和组织病理学检查报告，术前评估血红蛋白水平、白细胞、中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞和血小板计数结果，中性粒细胞-淋巴细胞比值和血小板-淋巴细胞比值值，c反应蛋白（CRP）和红细胞沉降率（ESR）水平。转移组CRP水平（143.10 mg/L）高于胶质瘤组（23.90 mg/L）；当CRP值为> ~ 55.00 mg/L时，区分转移性脑瘤和胶质母细胞瘤的敏感性为82%，特异性为75%。GOS评分与血红蛋白水平、ESR与CRP值呈正相关。GOS评分与ESR水平和住院时间呈负相关。研究结果表明，CRP值可作为区分转移性脑肿瘤和胶质母细胞瘤的预测性生物标志物。ESR、CRP、血红蛋白水平和住院时间可作为预测孤立性脑肿瘤患者短期预后的预后生物指标。
Radiological and/or laboratory tests may be sometimes inadequate distinguishing glioblastoma from metastatic brain tumors. The aim of this study was to find possible predictive biomarkers produced from routine blood biochemistry analysis results evaluated preoperatively in each patient with solitary brain tumor in distinguishing glioblastoma from metastatic brain tumors as well as revealing short-term prognosis. Patients admitted to neurosurgery clinic between January 2015 and September 2018 were included in this study and they were divided into GLIOMA (n=12) and METASTASIS (n=17) groups. Patients' data consisted of age, gender, Glasgow Coma Scale scores, duration of stay in hospital, Glasgow Outcome Scale (GOS) scores and histopathological examination reports, hemoglobin level, leukocyte, neutrophil, lymphocyte, monocyte, eosinophil, basophil and platelet count results, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio values, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were evaluated preoperatively. The CRP levels of METASTASIS group (143.10 mg/L) were higher than those of GLIOMA group (23.90 mg/L); and it was 82% sensitive and 75% specific in distinguishing metastatic brain tumor from glioblastoma if CRP value was >55.00 mg/L. A positive correlation was determined between GOS score and hemoglobin level and between ESR and CRP values. However, GOS scores were negatively correlated with the ESR level and duration of stay in hospital. Study results demonstrated that CRP values could be predictive biomarker in distinguishing metastatic brain tumor from glioblastoma. In addition, ESR, CRP, hemoglobin levels and duration of stay in hospital could be prognostic biomarkers in predicting short-term prognosis of patients with solitary brain tumor.
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影响因子：
2.9
作者：
Yang, Guang;Jones, Timothy L.;Howe, Franklyn A.
通讯作者：
Howe, Franklyn A.
影响因子：
45.3
作者：
Chaturvedi, Anil K.;Caporaso, Neil E.;Engels, Eric A.
通讯作者：
Engels, Eric A.
影响因子：
2.6
作者：
Hu Juan;Wang Qijun;Liu Junlan
通讯作者：
Liu Junlan
影响因子：
3.9
作者：
Bunevicius, Adomas;Radziunas, Andrius;Deltuva, Vytenis
通讯作者：
Deltuva, Vytenis
影响因子：
3.5
作者：
Cha, S.;Lupo, J. M.;Dillon, W. P.
通讯作者：
Dillon, W. P.