Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter.
Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter.
复制标题
DOI：
10.1016/j.pbb.2011.10.003
复制
发表时间：
2012-01
影响因子：
3.6
通讯作者：
Bevins, Rick A.
中科院分区：
文献类型：
--
作者：
Dion, Amanda M.;Sanderson, Scott C.;Murrin, L. Charles;Bevins, Rick A.
关键词：
被诊断患有抑郁症的人也往往有共同的尼古丁成瘾。因此，人们对用于治疗抑郁症的药物是否会改变尼古丁的作用感兴趣。本研究评估了抗抑郁药物西酞普兰、丙咪嗪和瑞波西汀对5-羟色胺和去甲肾上腺素转运蛋白具有不同特异性，是否改变了尼古丁条件刺激（CS）效应控制的反应。大鼠接受混合的20分钟尼古丁（0.4 mg碱/kg，SC）和生理盐水治疗。在尼古丁会议上，大鼠间歇性地获得蔗糖，没有蔗糖可在盐水会议。在辨别性能稳定并建立尼古丁泛化曲线（0.025-0.4 mg/kg）后，评估抗抑郁药物。在这些测试中，在训练剂量的尼古丁之前，用西酞普兰（1-17 mg/kg）、丙咪嗪（1-17 mg/kg）或瑞波西汀（1-30 mg/kg）对大鼠进行预处理，并将其置于室中进行4分钟消退测试。在较高剂量下，所有三种抗抑郁药都阻断了尼古丁CS诱发的反应，并降低了尼古丁诱导的多动症。当这些较高剂量的西酞普兰、丙咪嗪和瑞波西汀单独测试时（无尼古丁），它们降低了室活动和/或勺式进入。然而，所有三种药物在对勺式入口或腔室入口无影响的剂量下均能部分或完全阻断尼古丁的CS效应。这一发现表明，这两种神经递质在尼古丁的CS效应中发挥作用，抗抑郁药对这些系统的修饰可能具有临床意义。
People diagnosed with depression also tend to have a co-morbid nicotine addiction. Thus, there is interest in whether medications used to treat depression alter the effects of nicotine. This study assessed whether the antidepressant drugs citalopram, imipramine, and reboxetine, with differing specificity for the serotonin and norepinephrine transporter, altered responding controlled by the conditional stimulus (CS) effects of nicotine. Rats received intermixed 20-min nicotine (0.4 mg base/kg, SC) and saline sessions. On nicotine sessions, rats had intermittent access to sucrose; no sucrose was available on saline sessions. After discrimination performance stabilized and a nicotine generalization curve (0.025–0.4 mg/kg) was established, the antidepressant drugs were assessed. In these tests, rats were pretreated with citalopram (1–17 mg/kg), imipramine (1–17 mg/kg), or reboxetine (1–30 mg/kg) before the training dose of nicotine and placement in a chamber for a 4-min extinction test. At the higher doses, all three antidepressant drugs blocked responding evoked by the nicotine CS and decreased nicotine-induced hyperactivity. When these higher doses of citalopram, imipramine, and reboxetine were tested alone (no nicotine), they decreased chamber activity and/or dipper entries. Nevertheless, all three drugs produced partial or complete blockade of the CS effects of nicotine at doses that produced no effect on dipper entries or chamber entries. This finding suggests that both neurotransmitters play a role in the CS effects of nicotine and that modifications in these systems by antidepressants may be clinically relevant.
登录
查看更多内容
影响因子：
3.4
作者：
Evenden, JL
通讯作者：
Evenden, JL
影响因子：
120.7
作者：
ANDA, RF;WILLIAMSON, DF;REMINGTON, PL
通讯作者：
REMINGTON, PL
影响因子：
3.4
作者：
Besheer, J;Palmatier, MI;Bevins, RA
通讯作者：
Bevins, RA
DOI：
10.1124/jpet.303.2.664
发表时间：
2002-11-01
影响因子：
3.5
作者：
Rauhut, AS;Mullins, SN;Bardo, MT
通讯作者：
Bardo, MT
DOI：
10.1124/jpet.102.033852
发表时间：
2002-09-01
影响因子：
3.5
作者：
Miller, DK;Sumithran, SP;Dwoskin, LP
通讯作者：
Dwoskin, LP