Evidence of increased muscle atrophy and impaired quality of life parameters in patients with uremic restless legs syndrome.
Evidence of increased muscle atrophy and impaired quality of life parameters in patients with uremic restless legs syndrome.
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DOI：
10.1371/journal.pone.0025180
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Stefanidis I
中科院分区：
文献类型：
--
作者：
Giannaki CD;Sakkas GK;Karatzaferi C;Hadjigeorgiou GM;Lavdas E;Liakopoulos V;Tsianas N;Koukoulis GN;Koutedakis Y;Stefanidis I
不宁腿综合征是血液透析患者中非常常见的疾病。不宁腿综合征对生活质量产生负面影响;然而，尚不清楚这是否是由于精神或身体参数以及综合征与影响生存的参数之间是否存在关联。采用不宁腿综合征标准和睡眠中存在周期性肢体运动（PLMS/h> 15），评估70名临床稳定的血液透析患者，并将其分为RLS（n = 30）和非RLS（n = 40）组。 通过一系列测试评估身体表现：通过双能X射线吸收法测量身体成分，通过计算机断层扫描测量肌肉大小和成分，而抑郁症状，睡眠质量和生活质量的感知通过有效的问卷进行评估。在该横断面分析中，与非RLS组相比，RLS组显示大腿肌肉萎缩的证据。RLS组的睡眠质量和抑郁评分明显受损。RLS组的生活质量问卷的精神成分明显减少，从而降低了整体生活质量评分。相比之下，在任何身体性能测试、身体和肌肉组成方面，组间没有显著差异。不宁腿综合征HD患者报告的低水平生活质量似乎主要是由于心理健康和睡眠相关方面。在RLS组中也观察到肌肉萎缩的证据增加，这可能归因于缺乏恢复性睡眠。
Restless Legs Syndrome is a very common disorder in hemodialysis patients. Restless Legs Syndrome negatively affects quality of life; however it is not clear whether this is due to mental or physical parameters and whether an association exists between the syndrome and parameters affecting survival. Using the Restless Legs Syndrome criteria and the presence of Periodic Limb Movements in Sleep (PLMS/h >15), 70 clinically stable hemodialysis patients were assessed and divided into the RLS (n = 30) and non-RLS (n = 40) groups. Physical performance was evaluated by a battery of tests: body composition by dual energy X ray absorptiometry, muscle size and composition by computer tomography, while depression symptoms, perception of sleep quality and quality of life were assessed through validated questionnaires. In this cross sectional analysis, the RLS group showed evidence of thigh muscle atrophy compared to the non-RLS group. Sleep quality and depression score were found to be significantly impaired in the RLS group. The mental component of the quality of life questionnaire appeared significantly diminished in the RLS group, reducing thus the overall quality of life score. In contrast, there were no significant differences between groups in any of the physical performance tests, body and muscle composition. The low level of quality of life reported by the HD patients with Restless Legs Syndrome seems to be due mainly to mental health and sleep related aspects. Increased evidence of muscle atrophy is also observed in the RLS group and possibly can be attributed to the lack of restorative sleep.
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影响因子：
6.1
作者：
Mucsi, F;Molnar, MZ;Novak, M
通讯作者：
Novak, M
影响因子：
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影响因子：
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作者：
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通讯作者：
Reiss, D
影响因子：
--
作者：
Allen, RP;Walters, AS;Ferini-Strambi, L
通讯作者：
Ferini-Strambi, L