Imbalance between Th17 and regulatory T-Cells in sarcoidosis.
Imbalance between Th17 and regulatory T-Cells in sarcoidosis.
复制标题
结节病中 Th17 和调节性 T 细胞之间的失衡
DOI：
10.3390/ijms141121463
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发表时间：
2013-10-30
影响因子：
5.6
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Huang H;Lu Z;Jiang C;Liu J;Wang Y;Xu Z
结节病是一种全身性肉芽肿性疾病，被认为是由异常的免疫反应引起的。CD 4 + T淋巴细胞在肉芽肿的发生发展中起重要作用。以前，结节病的免疫发病机制集中在Th 1/Th 2紊乱。本研究的目的是评估新生CD 4 + T淋巴细胞之间的平衡，即，Treg和Th 17细胞。在我们的研究中，在结节病患者的外周血和BALF中观察到Treg细胞减少和Th 17细胞增加。在结节病患者中观察到Th 17/Treg细胞比率的显著增加。泼尼松治疗后，外周血Foxp 3 mRNA表达升高，（ROR）γt mRNA表达呈下降趋势。这些发现表明结节病与外周血和BALF中Th 17和Treg细胞之间的失衡有关。因此，靶向影响Th 17/Treg比率的细胞因子可能为肺结节病提供新的有希望的治疗。
Sarcoidosis is a systemic granulomatous disease, which is thought to result from an aberrant immune response. CD4+ T lymphocytes play an important role in the development of granulomas. Previously, the immunopathogenesis of sarcoidosis was focused on Th1/Th2 disturbances. The aim of this study was to evaluate the balance between newer CD4+ T lymphocytes, i.e., Treg and Th17 cells. In our studies, a decrease in Treg cells and an increase in Th17 cells were observed in the peripheral blood and BALF of sarcoidosis patients. A significant increase in the Th17/Treg cell ratio was observed in sarcoidosis patients. After treatment with prednisone, the expression of Foxp3 mRNA was elevated in the peripheral blood, and expression of (ROR)γt mRNA showed a downward trend. These findings suggest that sarcoidosis is associated with an imbalance between Th17 and Treg cells in peripheral blood and BALF. Therefore, targeting the cytokines that affect the Th17/Treg ratio could provide a new promising therapy for pulmonary sarcoidosis.
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影响因子：
9.6
作者：
Crouser, Elliott D.;Lozanski, Gerard;Julian, Mark W.
通讯作者：
Julian, Mark W.
影响因子：
8.6
作者：
Rappl, Gunter;Pabst, Stefan;Abken, Hinrich
通讯作者：
Abken, Hinrich
影响因子：
4.6
作者：
Rong, G.;Zhou, Y.;Zhong, R.
通讯作者：
Zhong, R.
影响因子：
4.9
作者：
Romagnani S
通讯作者：
Romagnani S
DOI：
10.2741/3657
发表时间：
2010-06-01
期刊：
Frontiers in bioscience (Landmark edition)
影响因子：
--
作者：
Mai J;Wang H;Yang XF
通讯作者：
Yang XF