Environmental hotspots for antibiotic resistance genes.
Environmental hotspots for antibiotic resistance genes.
复制标题
抗生素耐药基因的环境热点。
DOI：
10.1002/mbo3.1197
复制
发表时间：
2021-06
期刊：
影响因子：
3.4
通讯作者：
Petrovski S
中科院分区：
文献类型：
--
作者：
Kunhikannan S;Thomas CJ;Franks AE;Mahadevaiah S;Kumar S;Petrovski S
近年来，细菌对广谱抗生素的耐药性已成为一个主要问题。感染性细菌构成的威胁以及耐药性决定因素的传播速度需要被破译。土壤和水包含独特和多样化的微生物群落，以及自然产生的抗生素耐药性基因池。抗生素的过度使用以及糟糕的卫生做法使这些本土微生物群落暴露在来自其他细菌的抗生素耐药性基因之下，并加速了获得和传播的过程。大多数抗生素处方的临床环境被认为是一个主要的热点。周围环境对抗生素耐药细菌池的易感性促进了土壤、水和临床环境中的本土微生物群通过水平基因转移快速产生抗生素耐药性。这为发展更多耐多药病原菌提供了有利条件。在检测基因转移机制方面的局限性可能会让我们低估周围环境热点在耐多药细菌出现中所起的作用。这篇综述旨在找出导致抗生素耐药性传播的主要驱动因素和获得抗生素耐药性基因的热点。抗生素污染或废物进入各种不同的环境环境。抗生素的积累会对编码耐药基因的细菌造成选择性压力，从而产生耐药基因的热点。这些热点有助于抗生素耐药性基因在环境中的传播。
Bacterial resistance toward broad‐spectrum antibiotics has become a major concern in recent years. The threat posed by the infectious bacteria and the pace with which resistance determinants are transmitted needs to be deciphered. Soil and water contain unique and diverse microbial communities as well as pools of naturally occurring antibiotics resistant genes. Overuse of antibiotics along with poor sanitary practices expose these indigenous microbial communities to antibiotic resistance genes from other bacteria and accelerate the process of acquisition and dissemination. Clinical settings, where most antibiotics are prescribed, are hypothesized to serve as a major hotspot. The predisposition of the surrounding environments to a pool of antibiotic‐resistant bacteria facilitates rapid antibiotic resistance among the indigenous microbiota in the soil, water, and clinical environments via horizontal gene transfer. This provides favorable conditions for the development of more multidrug‐resistant pathogens. Limitations in detecting gene transfer mechanisms have likely left us underestimating the role played by the surrounding environmental hotspots in the emergence of multidrug‐resistant bacteria. This review aims to identify the major drivers responsible for the spread of antibiotic resistance and hotspots responsible for the acquisition of antibiotic resistance genes. Antibiotic contamination or waste enters a variety of different environmental settings. The accumulation of antibiotics can cause a selective pressure on bacteria that encode resistance genes for their survival, generating a hotspot for resistance genes. These hotspots contribute to the spread of antibiotic resistance genes in the environment.
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影响因子：
12.8
作者：
Cacace, Damiano;Fatta-Kassinos, Despo;Berendonk, Thomas U.
通讯作者：
Berendonk, Thomas U.
DOI：
10.1126/science.1220761
发表时间：
2012-08-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Forsberg KJ;Reyes A;Wang B;Selleck EM;Sommer MO;Dantas G
通讯作者：
Dantas G
影响因子：
7.7
作者：
Evans, Daniel R.;Griffith, Marissa P.;Van Tyne, Daria
通讯作者：
Van Tyne, Daria
影响因子：
12.8
作者：
Di Cesare, Andrea;Eckert, Ester M.;Corno, Gianluca
通讯作者：
Corno, Gianluca
影响因子：
5.5
作者：
Ayukekbong JA;Ntemgwa M;Atabe AN
通讯作者：
Atabe AN