Low-temperature rapid synthesis of high-stable carbon dots and its application in biochemical sensing
Low-temperature rapid synthesis of high-stable carbon dots and its application in biochemical sensing
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高稳定性碳点的低温快速合成及其在生化传感中的应用
DOI：
10.1016/j.dyepig.2020.108184
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发表时间：
2020-04
影响因子：
4.5
通讯作者：
Feng Bo
中科院分区：
文献类型：
--
作者：
Long Caicheng;Qing Taiping;Fu Qing;Jiang Zixin;Xu Jin;Zhang Peng;Feng Bo
碳点在化学传感器、电催化和光催化等方面有着广泛的应用，但大多数碳点的制备需要高温和长时间的反应。本文采用化学氧化和表面钝化的方法，分别以磷酸和氢氧化铵为氧化剂和钝化剂，在低温条件下合成荧光CDs。制备的CDs具有356nm和440nm两个不同激发波长的发射带，且量子产率高（25.51%）。更重要的是，即使在宽pH范围或高离子强度下，荧光CDs也表现出良好的水溶性和高生物相容性。此外，基于抗坏血酸与CDs之间的内过滤效应（IFE），该高稳定性荧光CDs还被用作抗坏血酸检测的比例荧光探针。该方法对缓冲液和生物样品的抗坏血酸分析均具有良好的灵敏度和选择性，为抗坏血酸在临床诊断中的检测提供了有价值的平台。
Carbon dots (CDs) have wide applications in chemical sensor, electrocatalysis, and photocatalysis, but most preparations of carbon dots need high temperature and long reaction time. In this work, a chemical oxidation and surface passivation approach was introduced to synthesize fluorescent CDs in low-temperature condition using phosphoric acid and ammonium hydroxide as the oxidant and passivator, respectively. The as-prepared CDs exhibited two emission bands at 356 nm and 440 nm with different excited wavelengths, and high quantum yield (25.51%). More important, the fluorescent CDs display good water-solubility and high biocompatibility even under broad pH range or high ionic strengths. Moreover, this high-stable fluorescent CDs was also employed as a ratiometric fluorescence probe for ascorbic acid sensing based on the inner filter effect (IFE) between ascorbic acid and CDs. This strategy represented excellent sensitivity and selectivity for ascorbic acid analysis both in buffer and biological samples, providing a valuable platform for ascorbic acid detection in clinic diagnosis.
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