GPR109a: the missing link between microbiome and good health?

GPR109a: the missing link between microbiome and good health?
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DOI:
10.1016/j.immuni.2013.12.009
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发表时间:
2014-01-16
期刊:
影响因子:
32.4
通讯作者:
Jobin, Christian
Jobin, Christian
中科院分区:
医学1区
文献类型:
--
作者:
Jobin, Christian

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宿主和庞大的肠道微生物生态系统之间复杂的伙伴关系服务于许多生物活动,包括营养、免疫和屏障功能。在本期《免疫》中,证明微生物来源的丁酸盐通过 GPR109a 信号传导介导其针对炎症和结直肠癌的保护活性。
A complex partnership between the host and the vast intestinal microbial ecosystem serves numerous biological activities including nutrition, immunity, and barrier function. In this issue of Immunity, demonstrate that microbial-derived butyrate mediated its protective activity against inflammation and colorectal cancer through GPR109a signaling.
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