Low-dose atropine attenuates muscle sympathetic nerve activity in healthy humans.
Low-dose atropine attenuates muscle sympathetic nerve activity in healthy humans.
复制标题
低剂量阿托品会减弱健康人的肌肉交感神经活动。
作者：
T. Yuasa;S. Takata;M. Maruyama;K. Yasuma;H. Yoshizawa;M. Kontani;H. Nagai;S. Sakagami;K. Kobayashi
Central muscarinic receptors play an important role in the regulation of cardiac vagal nerve activity. We studied the inhibition of central muscarinic receptors and sympathetic nerve function in humans, since very little information is currently available on this subject. We examined the effects of graded doses of atropine (five doses, range 0.001 to 0.016 mg/kg) on heart rate, arterial pressure, heart rate variability, and muscle sympathetic nerve activity in 13 healthy young volunteers. Atropine caused biphasic effects on heart rate and the high-frequency (HF) power of R-R interval variability. At lower doses (< or =0.002 mg/kg for heart rate, 0.001 mg/kg for HF power), atropine decreased heart rate and increased HF power. In contrast, at higher doses, atropine increased heart rate and decreased HF power. Low-dose atropine significantly attenuated muscle sympathetic nerve activity, burst rate (bursts/min) by -30.5 +/- 6.0% and burst incidence (bursts/100 heart beats) by -23.8 +/- 6.9% at 0.002 mg/kg. Systolic and diastolic arterial pressure did not change with atropine infusion. Low-dose atropine (< or =0.002 mg/kg) did not significantly affect either low frequency (LF) power or LF/HF. These results suggest that central muscarinic receptors may modulate not only cardiac vagal nerve activity but also sympathetic nerve activity in the skeletal muscle vasculature.
登录
查看更多内容
影响因子：
15.9
作者：
PORTER, TR;ECKBERG, DL;MOHANTY, PK
通讯作者：
MOHANTY, PK
DOI：
--
发表时间：
1996-12
期刊：
Journal of hypertension. Supplement : official journal of the International Society of Hypertension
影响因子：
--
作者：
A. Mark
通讯作者：
A. Mark
毒蕈碱胆碱能受体调节人类迷走神经心脏反应。
DOI：
10.1016/0165-1838(83)90080-2
发表时间：
1983
期刊：
Journal of the autonomic nervous system
影响因子：
--
作者：
Raczkowska,M;Eckberg,DL;Ebert,TJ
通讯作者：
Ebert,TJ
影响因子：
56.9
作者：
MASH, DC;FLYNN, DD;POTTER, LT
通讯作者：
POTTER, LT
东莨菪碱诱导的人类迷走神经-心脏神经活动的基线水平和反射增强水平的长期增加。
影响因子：
37.8
作者：
Dibner-Dunlap,ME;Eckberg,DL;Magid,NM;Cintrón-Treviño,NM
通讯作者：
Cintrón-Treviño,NM