Virtual reality video game improves high-fidelity memory in older adults.
Virtual reality video game improves high-fidelity memory in older adults.
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DOI：
10.1038/s41598-021-82109-3
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发表时间：
2021-01-28
影响因子：
4.6
通讯作者：
Gazzaley A
中科院分区：
文献类型：
--
作者：
Wais PE;Arioli M;Anguera-Singla R;Gazzaley A
治疗干预尚未显示出对影响许多健康老年人的长期记忆（LTM）下降的恢复作用。我们开发了一个虚拟现实（VR）空间寻路游戏（Laborth-VR）作为认知干预，假设它可以提高详细的，高保真的LTM能力。空间导航任务已被用作一种手段，以实现环境丰富，通过接触和了解新的和复杂的信息。参与已被证明可以增强学习，并与大脑中LTM系统的活力有关。在目前的研究中，48名具有平均认知能力的老年人（平均年龄68.7 ± 6.4岁）被随机分配到为期四周的12小时的电脑游戏中，分为Laborith-VR或安慰剂对照游戏组。在每个参与者的治疗方案之前和之后，对高保真LTM结果测量进行了测试，以评估记忆辨别力和其他记忆测量。结果显示，相对于安慰剂，Labelth-VR手臂的高保真LTM能力在治疗后获得了提高，达到了另一项实验中年轻人达到的水平。这一新的发现证明了VR寻路游戏对重要的、未经训练的LTM能力的好处。这些认知结果进行了讨论，根据相关的研究，依赖于记忆功能。
Therapeutic interventions have not yet been shown to demonstrate restorative effects for declining long-term memory (LTM) that affects many healthy older adults. We developed a virtual reality (VR) spatial wayfinding game (Labyrinth-VR) as a cognitive intervention with the hypothesis that it could improve detailed, high-fidelity LTM capability. Spatial navigation tasks have been used as a means to achieve environmental enrichment via exposure to and learning about novel and complex information. Engagement has been shown to enhance learning and has been linked to the vitality of the LTM system in the brain. In the current study, 48 older adults (mean age 68.7 ± 6.4 years) with average cognitive abilities for their age were randomly assigned to 12 h of computer game play over four weeks in either the Labyrinth-VR or placebo control game arms. Promptly before and after each participant’s treatment regimen, high-fidelity LTM outcome measures were tested to assess mnemonic discrimination and other memory measures. The results showed a post-treatment gain in high-fidelity LTM capability for the Labyrinth-VR arm, relative to placebo, which reached the levels attained by younger adults in another experiment. This novel finding demonstrates generalization of benefits from the VR wayfinding game to important, and untrained, LTM capabilities. These cognitive results are discussed in the light of relevant research for hippocampal-dependent memory functions.
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影响因子：
6.9
作者：
Coluccia, E;Louse, G
通讯作者：
Louse, G
影响因子：
3.5
作者：
Bilkey DK;Cheyne KR;Eckert MJ;Lu X;Chowdhury S;Worley PF;Crandall JE;Abraham WC
通讯作者：
Abraham WC
影响因子：
2.4
作者：
Chalfonte, BL;Johnson, MK
通讯作者：
Johnson, MK
影响因子：
3.7
作者：
FERGUSON, SA;HASHTROUDI, S;JOHNSON, MK
通讯作者：
JOHNSON, MK
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.