Exposure to complex environments results in more sparse representations of space in the hippocampus.
Exposure to complex environments results in more sparse representations of space in the hippocampus.
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DOI：
10.1002/hipo.22762
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发表时间：
2017-11
期刊：
影响因子：
3.5
通讯作者：
Abraham WC
中科院分区：
文献类型：
--
作者：
Bilkey DK;Cheyne KR;Eckert MJ;Lu X;Chowdhury S;Worley PF;Crandall JE;Abraham WC
调节感觉和运动表征的神经回路通过动物与其环境的相互作用而自适应地调整。类似地，高阶表征（如空间记忆）可以通过暴露于复杂环境（CE）来改变，但在这种情况下，介导这种效应的大脑回路的变化还不太清楚。在这里，我们表明，长期CE曝光与增加的选择性CA 1“位置细胞”，以一个特定的记录竞技场相比，社会控制（SC）组。此外，CE组中较少的CA1和DG神经元表达高水平的Arc蛋白，这是最近激活的标志物，短暂暴露于全新的环境后。Arc表达的减少与细胞密度或数量的总体变化无关。这些数据表明，CE暴露的影响之一是通过增加神经元网络内群体编码的稀疏性来修改大脑中的高水平空间表征。更大的稀疏性可能导致更有效和紧凑的编码系统，这可能会改变空间任务的行为表现。行为实验的结果与这一假设一致，因为CE处理的动物更快地适应新的环境，尽管表现出相同的初始反应。
The neural circuitry mediating sensory and motor representations is adaptively tuned by an animal's interaction with its environment. Similarly, higher order representations such as spatial memories can be modified by exposure to a complex environment (CE), but in this case the changes in brain circuitry that mediate the effect are less well understood. Here we show that prolonged CE exposure was associated with increased selectivity of CA1 “place cells” to a particular recording arena compared to a social control (SC) group. Furthermore, fewer CA1 and DG neurons in the CE group expressed high levels of Arc protein, a marker of recent activation, following brief exposure to a completely novel environment. The reduced Arc expression was not attributable to overall changes in cell density or number. These data indicate that one effect of CE exposure is to modify high-level spatial representations in the brain by increasing the sparsity of population coding within networks of neurons. Greater sparsity could result in a more efficient and compact coding system that might alter behavioural performance on spatial tasks. The results from a behavioural experiment were consistent with this hypothesis, as CE-treated animals habituated more rapidly to a novel environment despite showing equivalent initial responding.
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DOI：
10.1085/jgp.116.2.191
发表时间：
2000-08
期刊：
The Journal of general physiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.5
作者：
Irvine, GI;Abraham, WC
通讯作者：
Abraham, WC
影响因子：
3.7
作者：
Kyd, RJ;Bilkey, DK
通讯作者：
Bilkey, DK
影响因子：
64.8
作者：
Kempermann, G;Kuhn, HG;Gage, FH
通讯作者：
Gage, FH
DOI：
10.1098/rstb.1977.0050
发表时间：
1977-01-01
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
HUBEL, DH;WIESEL, TN;LEVAY, S
通讯作者：
LEVAY, S