Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression.
Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression.
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DOI：
10.1001/archgenpsychiatry.2011.1385
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发表时间：
2012-03
影响因子：
--
通讯作者：
Nelson, Elliot C.
中科院分区：
文献类型：
--
作者：
Sartor, Carolyn E.;Grant, Julia D.;Lynskey, Michael T.;McCutcheon, Vivia V.;Waldron, Mary;Statham, Dixie J.;Bucholz, Kathleen K.;Madden, Pamela A. F.;Heath, Andrew C.;Martin, Nicholas G.;Nelson, Elliot C.
了解遗传和环境因素在创伤暴露、创伤后应激障碍（PTSD）和重度抑郁症（MDD）中的相对作用，对于建立这些疾病及其共发的病因学模型至关重要。量化对低风险创伤、高风险创伤、创伤后应激障碍和重度抑郁症的遗传影响，并估计这4种表型变异的遗传和环境来源之间的重叠程度。成年双胞胎及其兄弟姐妹是根据先前对该队列的评估中获得的儿童性虐待和身体虐待筛查项目，从基于大量人口的女性和男性双胞胎样本中确定的。结构化精神病学电话访谈。总样本量2591：女性996对，男性536对；625名女性和434名男性非双胞胎兄弟姐妹。终生低风险和高风险的创伤暴露，PTSD和重度抑郁症。在最合适的遗传模型中，47%的低风险创伤暴露变异和60%的高风险创伤暴露变异可归因于加性遗传因素。遗传影响占创伤后应激障碍变异的46%，占重度抑郁症变异的27%。高危创伤暴露与PTSD （r =0.89; 95% CI, 0.78-0.99）和MDD （r =0.89; 95% CI, 0.77-0.98）之间存在极高程度的遗传重叠。观察到导致PTSD和MDD的遗传因素完全相关（r=1.00）。有证据表明，几乎所有对高危创伤暴露、PTSD和重度抑郁症的遗传影响都可以追溯到相同的来源；也就是说，遗传风险并不是疾病特有的。有创伤后应激障碍或重度抑郁症家族史的个体患这两种疾病的风险较高，在创伤经历后应密切监测PTSD和重度抑郁症的症状。
Understanding the relative contributions of genetic and environmental factors to trauma exposure, post-traumatic stress disorder (PTSD), and major depressive disorder (MDD) is critical to developing etiologic models of these conditions and their co-occurrence. To quantify heritable influences on low-risk trauma, high-risk trauma, PTSD, and MDD and to estimate the degree of overlap between genetic and environmental sources of variance in these 4 phenotypes. Adult twins and their siblings were ascertained from a large population-based sample of female and male twin pairs on the basis of screening items for childhood sexual abuse and physical abuse obtained in a previous assessment of this cohort. Structured psychiatric telephone interviews. Total sample size of 2591: 996 female and 536 male twins; 625 female and 434 male nontwin siblings. Lifetime low- and high-risk trauma exposure, PTSD, and MDD. In the best-fitting genetic model, 47% of the variance in low-risk trauma exposure and 60% of the variance in high-risk trauma exposure was attributable to additive genetic factors. Heritable influences accounted for 46% of the variance in PTSD and 27% of the variance in MDD. An extremely high degree of genetic overlap was observed between high-risk trauma exposure and both PTSD (r =0.89; 95% CI, 0.78-0.99) and MDD (r =0.89; 95% CI, 0.77-0.98). Complete correlation of genetic factors contributing to PTSD and to MDD (r=1.00) was observed. The evidence suggests that almost all the heritable influences on high-risk trauma exposure, PTSD, and MDD, can be traced to the same sources; that is, genetic risk is not disorder specific. Individuals with a positive family history of either PTSD or MDD are at elevated risk for both disorders and should be closely monitored after a traumatic experience for symptoms of PTSD and MDD.
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影响因子：
17.7
作者：
Kendler, KS;Gardner, CO;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
4.1
作者：
Cox, BJ;MacPherson, PSR;McWilliams, LA
通讯作者：
McWilliams, LA
DOI：
10.1375/twin.4.2.73
发表时间：
2001-04-01
期刊：
Twin research : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Heath, A C;Howells, W;Martin, N G
通讯作者：
Martin, N G
影响因子：
10.6
作者：
Breslau, N;Davis, GC;Schultz, LR
通讯作者：
Schultz, LR