Lesions within the head direction system reduce retrosplenial c-fos expression but do not impair performance on a radial-arm maze task.
Lesions within the head direction system reduce retrosplenial c-fos expression but do not impair performance on a radial-arm maze task.
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DOI：
10.1016/j.bbr.2017.10.026
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发表时间：
2018-02-15
影响因子：
2.7
通讯作者：
Vann SD
中科院分区：
文献类型：
--
作者：
Vann SD
哺乳动物外侧核是头部方向系统中的一个中心结构，但关于这些核如何影响空间表现，目前还知之甚少。在本研究中，对选择性损毁乳头体外侧核的大鼠进行了放射臂迷宫中的工作记忆测试。这项任务要求动物区分八只径向的手臂，并记住它们在一次训练中进入了哪些手臂。尽管可能已经预测到这项任务会给头部方向系统带来沉重的负担，但损伤大鼠在这项任务上的表现与它们的手术对照组相当；即使在测试过程中旋转迷宫以减少对迷宫内线索的依赖，使任务变得更加困难，也没有出现赤字。随后，大鼠在黑暗中接受测试，以增加对内部产生的方向线索的使用，但损伤大鼠仍未受到损害。相反，损毁外侧乳头状核可降低脾后c-Fos水平。这些结果表明，获取标准的径向-臂迷宫任务不需要头部方向系统。这也表明，脾后c-fos的微小减少不足以产生行为障碍。
The lateral mammillary nuclei are a central structure within the head direction system yet there is still relatively little known about how these nuclei contribute to spatial performance. In the present study, rats with selective neurotoxic lesions of the lateral mammillary nuclei were tested on a working memory task in a radial-arm maze. This task requires animals to distinguish between eight radially-oriented arms and remember which arms they have entered within a session. Even though it might have been predicted that this task would heavily tax the head direction system, the lesion rats performed equivalently to their surgical controls on this task; no deficit emerged even when the task was made more difficult by rotating the maze mid-way through testing in order to reduce reliance on intramaze cues. Rats were subsequently tested in the dark to increase the use of internally generated direction cues but the lesion rats remained unimpaired. In contrast, the lateral mammillary nuclei lesions were found to decrease retrosplenial c-Fos levels. These results would suggest that the head direction system is not required for the acquisition of the standard radial-arm maze task. It would also suggest that small decreases in retrosplenial c-Fos are not sufficient to produce behavioural impairments.
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