Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study.
Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study.
复制标题
DOI：
10.1007/s10552-009-9436-6
复制
发表时间：
2010-01
影响因子：
2.3
通讯作者：
Savage, Sharon A.
中科院分区：
文献类型：
--
作者：
Mirabello, Lisa;Garcia-Closas, Montserrat;Cawthon, Richard;Lissowska, Jolanta;Brinton, Louise A.;Peplonska, Beata;Sherman, Mark E.;Savage, Sharon A.
端粒是染色体末端的结构，有助于维持基因组的完整性。端粒的缩短与细胞的重复分裂可能会导致基因组的不稳定性和致癌作用。研究表明，较短的端粒在宪法DNA与膀胱癌，乳腺癌，肺癌和肾癌。卵巢癌组织中也有端粒缩短和端粒酶活性增加，提示端粒异常可能与卵巢癌有关。我们调查了99名浆液性卵巢腺癌患者和100名年龄匹配的无癌对照者的白细胞端粒长度，这些患者参加了一项基于人群的病例对照研究。病例倾向于具有比对照更短的端粒（Pwilcoxon = 0.002）。与端粒长度在最长三分位数的受试者相比，在中间和最短三分位数的受试者显示出相应的年龄调整优势比（95%置信区间）为2.69（1.23-5.88）和3.39（1.54-7.46）（P趋势= 0.002）。低分化癌患者的相关性最强（OR = 4.89，95%CI 1.93-12.34）。这项研究表明短的白细胞端粒与浆液性卵巢腺癌有关。这些发现应该在大型前瞻性研究中得到证实。
Telomeres are structures at chromosome ends that contribute to maintaining genomic integrity. Telomere shortening with repeated cell divisions may lead to genomic instability and carcinogenesis. Studies suggest that shorter telomeres in constitutional DNA are associated with bladder, breast, lung, and renal cancer. Ovarian cancer tissues also have shortened telomeres and increased telomerase activity, suggesting that telomere abnormalities may be related to ovarian cancer. We investigated leukocyte telomere length in 99 women with serous ovarian adenocarcinoma and 100 age-matched cancer-free controls enrolled in a population-based case–control study. Cases tended to have shorter telomeres than controls (Pwilcoxon = 0.002). Compared to subjects with telomere lengths in the longest tertile, those in the middle and shortest tertiles showed respective age-adjusted odds ratios (95% confidence intervals) of 2.69 (1.23–5.88) and 3.39 (1.54–7.46) (Ptrend = 0.002). Strongest associations were found for subjects with poorly differentiated carcinomas (OR = 4.89, 95% CI 1.93–12.34). This study shows that short leukocyte telomeres are associated with serous ovarian adenocarcinoma. These findings should be confirmed in large, prospective studies.
登录
查看更多内容
影响因子：
14.9
作者：
Cawthon RM
通讯作者：
Cawthon RM
影响因子：
6.5
作者：
Fern, L;Pallis, M;Byrne, J
通讯作者：
Byrne, J
影响因子：
3.8
作者：
Garcia-Closas, Montserrat;Brinton, Louise A.;Chanock, Stephen J.
通讯作者：
Chanock, Stephen J.
影响因子：
13.5
作者：
Plentz, RR;Caselitz, M;Rudolph, KL
通讯作者：
Rudolph, KL
DOI：
10.1093/jnci/djg011
发表时间：
2003-08-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Wu, XF;Amos, CI;Spitz, MR
通讯作者：
Spitz, MR