Elevated serum pesticide levels and risk of Parkinson disease.
Elevated serum pesticide levels and risk of Parkinson disease.
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DOI：
10.1001/archneurol.2009.89
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发表时间：
2009-07
影响因子：
--
通讯作者：
German, Dwight C.
中科院分区：
文献类型：
--
作者：
Richardson, Jason R.;Shalat, Stuart L.;Buckley, Brian;Winnik, Bozena;O'Suilleabhain, Padraig;Diaz-Arrastia, Ramon;Reisch, Joan;German, Dwight C.
据报道，接触农药会增加帕金森病（PD）的风险，但缺乏对特定农药的识别。三项研究发现，死后PD大脑中有机氯农药水平升高。确定PD患者血清中有机氯农药水平是否升高。病例对照研究。学术医疗中心50例PD患者，43例对照组和20例阿尔茨海默病患者。血清样本中16种有机氯农药的水平。与对照组（40%）和阿尔茨海默病患者（30%）相比，帕金森病患者（76%）更容易检测到β-六氯环己烷（β-HCH）。与对照组和阿尔茨海默病患者相比，帕金森病患者的β-HCH中位水平较高。有没有显着的差异，在检测控制和患者之间的PD关于任何其他15种有机氯农药。最后，我们观察到血清中β-HCH的存在对预测PD与对照组的诊断（比值比，4.39; 95%置信区间，1.67-11.6）和PD与阿尔茨海默病的诊断（比值比，5.20）具有显著的比值比，这为血清β-HCH与PD之间的明显相关性提供了进一步的证据。这些数据表明，β-HCH与帕金森病的诊断有关。关于β-HCH作为某些PD病例的病原体的潜在作用，需要进一步研究。
Exposure to pesticides has been reported to increase the risk of Parkinson disease (PD), but identification of the specific pesticides is lacking. Three studies have found elevated levels of organochlorine pesticides in postmortem PD brains. To determine whether elevated levels of organochlorine pesticides are present in the serum of patients with PD. Case-control study. An academic medical center. Fifty patients with PD, 43 controls, and 20 patients with Alzheimer disease. Levels of 16 organochlorine pesticides in serum samples. β-Hexachlorocyclohexane (β-HCH) was more often detectable in patients with PD (76%) compared with controls (40%) and patients with Alzheimer disease (30%). The median level of β-HCH was higher in patients with PD compared with controls and patients with Alzheimer disease. There were no marked differences in detection between controls and patients with PD concerning any of the other 15 organochlorine pesticides. Finally, we observed a significant odds ratio for the presence of β-HCH in serum to predict a diagnosis of PD vs control (odds ratio, 4.39; 95% confidence interval, 1.67–11.6) and PD vs Alzheimer disease (odds ratio, 5.20), which provides further evidence for the apparent association between serum β-HCH and PD. These data suggest that β-HCH is associated with a diagnosis of PD. Further research is warranted regarding the potential role of β-HCH as a etiologic agent for some cases of PD.
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影响因子：
3.4
作者：
Kanthasamy, AG;Kitazawa, M;Anantharam, V
通讯作者：
Anantharam, V
影响因子：
3.4
作者：
Petersen, Maria Skaalum;Halling, Jonrit;Grandjean, Philippe
通讯作者：
Grandjean, Philippe
影响因子：
11.2
作者：
Hernán, MA;Takkouche, B;Gestal-Otero, JJ
通讯作者：
Gestal-Otero, JJ
影响因子：
--
作者：
O'Suilleabhain, PE;Sung, V;Diaz-Arrastia, R
通讯作者：
Diaz-Arrastia, R
环境污染物和人类健康风险分析中的脂质调整。
影响因子：
10.4
作者：
Schisterman, EF;Whitcomb, BW;Louis, GMB;Louis, TA
通讯作者：
Louis, TA