Genetic variation and obesity in Australian women: a prospective study.
Genetic variation and obesity in Australian women: a prospective study.
复制标题
澳大利亚女性的遗传变异和肥胖：一项前瞻性研究。
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
G. R. Collier
中科院分区：
文献类型：
--
作者：
Andrea M. de Silva;Ken R. Walder;Edward J. Boyko;Kate F. Whitecross;Geoff Nicholson;M. Kotowicz;Julie A. Pasco;G. R. Collier
目的
许多候选基因与人类肥胖症的发病机制有关。本研究探讨了澳大利亚女性队列中体重和成分的纵向变化与β-3肾上腺素能受体、肿瘤坏死因子-α、瘦素和瘦素受体（Lepr）多态性之间的关系。
研究方法和程序
从维多利亚的Barwon地区随机选择健康的白色澳大利亚妇女（n = 335），并进行基线人体测量和双能X线吸收测定法评估体重和肥胖。在2年随访时再次重复这些测量。提取基因组DNA并用于所有多态性的基于聚合酶链反应的基因分型。
结果
在这项研究中，Pro 1019 Pro Lepr多态性与体重（p = 0.02）、脂肪量（p = 0.05）和体重指数（p = 0.01）的纵向增加相关，该基因座A等位基因纯合子个体随时间推移有更大的体脂增加倾向。对身体成分影响最大的似乎是在基线时已经肥胖的个体。在非肥胖或肥胖女性中，2年内体重、脂肪量、体脂百分比和体重指数的变化与β-3肾上腺素能受体（Trp 64 Arg）、肿瘤坏死因子-α启动子或瘦素基因的遗传变异无关。
讨论
这些结果表明，Lepr基因多态性参与调节肥胖的澳大利亚白色妇女的体重和肥胖，这可能对治疗肥胖在这一人群的影响。
OBJECTIVE
A number of candidate genes have been implicated in the pathogenesis of obesity in humans. This study examines associations between longitudinal changes in body mass and composition and the presence of polymorphisms in the beta-3 adrenergic receptor, tumor necrosis factor-alpha, leptin, and leptin receptor (Lepr) in a cohort of Australian women.
RESEARCH METHODS AND PROCEDURES
Healthy white Australian women (n = 335) were randomly selected from the Barwon region of Victoria and underwent baseline anthropometry and double-energy X-ray absorptiometry for assessment of body mass and adiposity. These measurements were repeated again at 2-year follow-up. Genomic DNA was extracted and used for polymerase chain reaction-based genotyping of all polymorphisms.
RESULTS
The Pro1019Pro Lepr polymorphism was associated with longitudinal increases in body weight (p = 0.02), fat mass (p = 0.05), and body mass index (p = 0.01) in this study, and individuals homozygous for the A allele at this locus had a greater propensity to gain body fat over time. The largest effects on body composition seemed to be in individuals already obese at baseline. Changes in body weight, fat mass, percent body fat, and body mass index over a 2-year period were not associated with genetic variation in the beta-3 adrenergic receptor (Trp64Arg), tumor necrosis factor-alpha promoter, or leptin genes in non-obese or obese women.
DISCUSSION
These results suggest that a Lepr polymorphism is involved in the regulation of body mass and adiposity in obese Australian white women, which may have implications for the treatment of obesity in this population.
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影响因子：
158.5
作者：
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