Significance of desmoplastic reactions on tumor deposits in patients with colorectal cancer.
Significance of desmoplastic reactions on tumor deposits in patients with colorectal cancer.
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DOI：
10.3892/ol.2022.13587
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发表时间：
2023-01
期刊：
影响因子：
2.9
通讯作者：
Sekimoto M
中科院分区：
文献类型：
--
作者：
Kobayashi T;Ishida M;Miki H;Hatta M;Hamada M;Hirose Y;Sekimoto M
肿瘤微环境在肿瘤的进展和侵袭中起着重要作用。促结缔组织增生反应（DR）是肿瘤细胞周围的纤维组织反应，DR在结直肠癌（CRC）中的预后意义已得到证实。肿瘤沉积物（TD）也是CRC的重要预后指标。值得注意的是，不成熟型DR与预后不良有关。此外，未成熟型DR与较高的pT分期、淋巴管浸润和淋巴结转移显著相关;然而，据我们所知，DR与TD之间的相关性尚未得到研究。本研究旨在阐明这种关联。该研究纳入了443例连续的pT 3或pT 4 CRC患者，这些患者接受了手术切除。对DR、TD等组织病理学特征进行评价。对TD、DR和其他临床病理参数的存在进行统计学分析。本队列包括205例女性和238例男性患者;分别有293例（66.1%）和150例（33.9%）患者被归类为pT 3和pT 4。未成熟、中期和成熟DR分别为282例（63.7%）、91例（20.5%）和70例（15.8%）。93例（21.0%）患者观察到TD。未成熟型DR与较高的pT分期（P<0.0001）、淋巴结转移（P<0.0001）、淋巴管（P=0.0007）、静脉（P<0.0001）和神经周围浸润（P<0.0001）以及较高的肿瘤出芽（TB）（P<0.0001）显著相关。此外，不成熟型DR与TD的存在显著相关（P<0.0001）。目前的研究表明，未成熟型DR与TD的存在之间存在显着的联系，并建议淋巴管浸润，DR，TB和TD之间的密切关系。需要更多的研究来分析CRC中不成熟DR发展的详细机制，以确定新的治疗策略。
It has been well recognized that the tumor microenvironment serves important roles in the progression and invasion of cancer. The desmoplastic reaction (DR) is a fibrous tissue reaction around tumor cells, and the prognostic significance of DR in colorectal cancer (CRC) has been established. Tumor deposits (TD) are also an important prognostic indicator of CRC. Notably, immature type DR has been linked to poor prognosis. In addition, immature type DR is significantly associated with a higher pT stage, presence of lymphovascular invasion and lymph node metastasis; however, to the best of our knowledge, the association between DR and TD has not yet been examined. The present study aimed to clarify this association. This study included 443 consecutive patients with pT3 or pT4 CRC who underwent surgical resection. The histopathological features, including DR and TD, were evaluated. Statistical analyses of the presence of TD, DR and other clinicopathological parameters were performed. The present cohort included 205 female and 238 male patients; 293 (66.1%) and 150 (33.9%) patients were classified as pT3 and pT4, respectively. Immature, intermediate and mature DR were noted in 282 (63.7%), 91 (20.5%) and 70 patients (15.8%), respectively. TD was observed in 93 (21.0%) patients. Immature type DR was significantly associated with a higher pT stage (P<0.0001), presence of lymph node metastasis (P<0.0001), lymphatic (P=0.0007), venous (P<0.0001) and perineural invasion (P<0.0001), and higher tumor budding (TB) (P<0.0001). Moreover, immature type DR was significantly associated with the presence of TD (P<0.0001). The present study demonstrated a significant association between immature type DR and the presence of TD, and suggested a close relationship between lymphovascular invasion, DR, TB and TD. Additional studies are required to analyze the detailed mechanism underlying the development of immature DR in CRC to define novel treatment strategies.
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影响因子：
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作者：
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