Curvature forces in membrane lipid-protein interactions.
Curvature forces in membrane lipid-protein interactions.
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DOI：
10.1021/bi301332v
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发表时间：
2012-12-11
期刊：
影响因子：
2.9
通讯作者：
Brown MF
中科院分区：
文献类型：
--
作者：
Brown MF
膜生物化学家越来越意识到脂质-蛋白质相互作用在不同细胞功能中的作用。本文综述了膜蛋白的构象变化，包括折叠，稳定性和膜形状的转变，可能涉及弹性重塑的脂质双层。有证据表明，膜脂影响蛋白质通过相互作用的一个相对较长的范围内的性质，超出了一个单一的环相邻边界脂质。假设力的距离尺度比作用的分子范围大。弹性理论在柔性软表面的应用源于经典物理学，并解释了洗涤剂和膜磷脂的多态性。柔性表面模型（FSM）描述了脂质-蛋白质相互作用中曲率和疏水力的平衡。脂双层的非特异性化学性质调节膜蛋白的构象能。新的生物膜模型挑战了生物化学教科书中的标准模型（流体镶嵌模型）。首先介绍了视紫红质的数据为基础的曲率力场的想法提供了理论和实验之间的桥梁。双层厚度，非层状形成脂质，洗涤剂和渗透应力的影响都解释了FSM。对曲率力的认识的增加表明，随着结构生物学在解释膜结构和功能时与脂质的物理化学更加紧密地联系在一起，研究将加速。
Membrane biochemists are becoming increasingly aware of the role of lipid-protein interactions in diverse cellular functions. This review describes how conformational changes of membrane proteins—involving folding, stability, and membrane shape transitions—potentially involve elastic remodeling of the lipid bilayer. Evidence suggests that membrane lipids affect proteins through interactions of a relatively long-range nature, extending beyond a single annulus of next-neighbor boundary lipids. It is assumed the distance scale of the forces is large compared to the molecular range of action. Application of the theory of elasticity to flexible soft surfaces derives from classical physics, and explains the polymorphism of both detergents and membrane phospholipids. A flexible surface model (FSM) describes the balance of curvature and hydrophobic forces in lipid-protein interactions. Chemically nonspecific properties of the lipid bilayer modulate the conformational energetics of membrane proteins. The new biomembrane model challenges the standard model (the fluid mosaic model) found in biochemistry texts. The idea of a curvature force field based on data first introduced for rhodopsin gives a bridge between theory and experiment. Influences of bilayer thickness, nonlamellar-forming lipids, detergents, and osmotic stress are all explained by the FSM. An increased awareness of curvature forces suggests that research will accelerate as structural biology becomes more closely entwined with the physical chemistry of lipids in explaining membrane structure and function.
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DOI：
10.1038/nsb0295-139
发表时间：
1995-02-01
期刊：
NATURE STRUCTURAL BIOLOGY
影响因子：
--
作者：
BOOTH, PJ;FLITSCH, SL;KHORANA, HG
通讯作者：
KHORANA, HG
影响因子：
6.8
作者：
Booth, Paula J.
通讯作者：
Booth, Paula J.
DOI：
10.1073/pnas.85.15.5364
发表时间：
1988-08-01
影响因子：
11.1
作者：
ANDERSON, DM;GRUNER, SM;LEIBLER, S
通讯作者：
LEIBLER, S
影响因子：
2.9
作者：
BALDWIN, PA;HUBBELL, WL
通讯作者：
HUBBELL, WL
影响因子：
6.8
作者：
Booth, Paula J.;Curnow, Paul
通讯作者：
Curnow, Paul