Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma.
Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma.
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前列腺干细胞抗原基因表达与口腔鳞癌的相关性
DOI：
10.3892/ol.2018.8468
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发表时间：
2018-06
期刊：
影响因子：
2.9
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Zhao K;Li X;Wang J;Liu J;Gong W;Xu H;Wang J;Jiang L;Dan H;Li J;Zeng X;Chen Q
口腔鳞状细胞癌的病因尚不清楚。许多与癌症相关的单核苷酸多态性（snp）已经通过全基因组关联研究（GWAS）被鉴定出来。本研究旨在确定与癌症易感性相关的常见snp，并评估其在OSCC中的作用。通过分析癌症GWAS目录确定易感位点。采用OSCC和对照人群对选定的snp进行了多中心病例对照研究。利用逆转录聚合酶链反应、酶联免疫吸附试验和免疫组织化学对所选位点及其相关基因的功能进行了研究。对76例OSCC患者的基因型与临床参数的关系进行了评估。选取位于前列腺干细胞抗原基因（PSCA）中的Rs2294008。发现rs2294008多态性与OSCC易感性相关，PSCA可能参与OSCC的发生、发展和预后。
The aetiology of oral squamous cell carcinoma (OSCC) remains unclear. Numerous single nucleotide polymorphisms (SNPs) associated with cancer have been identified using genome-wide association studies (GWAS). The present study was designed to identify common SNPs associated with cancer susceptibility and to evaluate their involvement in OSCC. Susceptible loci were identified by analysing a cancer GWAS catalogue. A multicentre case-control study using an OSCC and control population was performed for selected SNPs. The function of the selected locus and its associated gene was explored using a reverse transcription-polymerase chain reaction, enzyme linked immunosorbent assay and immunohistochemistry. The association between genotypes and clinical parameters was assessed in 76 patients with OSCC. Rs2294008 located in the prostate stem cell antigen gene (PSCA) was selected. It was identified that the rs2294008 polymorphism was associated with OSCC susceptibility and PSCA may be involved in the development, progression and prognosis of OSCC.
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DOI：
10.1523/jneurosci.2271-09.2009
发表时间：
2009-11-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hruska M;Keefe J;Wert D;Tekinay AB;Hulce JJ;Ibañez-Tallon I;Nishi R
通讯作者：
Nishi R
DOI：
10.1056/nejmra0808700
发表时间：
2009-04-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hardy J;Singleton A
通讯作者：
Singleton A
影响因子：
3.1
作者：
Ou, JianFeng;Li, Kang;Zhang, ChongJie
通讯作者：
Zhang, ChongJie
影响因子：
8
作者：
Gu, Z;Thomas, G;Reiter, RE
通讯作者：
Reiter, RE
影响因子：
30.8
作者：
Levine, David M.;Ek, Weronica E.;Zhang, Rui;Liu, Xinxue;Onstad, Lynn;Sather, Cassandra;Lao-Sirieix, Pierre;Gammon, Marilie D.;Corley, Douglas A.;Shaheen, Nicholas J.;Bird, Nigel C.;Hardie, Laura J.;Murray, Liam J.;Reid, Brian J.;Chow, Wong-Ho;Risch, Harvey A.;Nyren, Olof;Ye, Weimin;Liu, Geoffrey;Romero, Yvonne;Bernstein, Leslie;Wu, Anna H.;Casson, Alan G.;Chanock, Stephen J.;Harrington, Patricia;Caldas, Isabel;Debiram-Beecham, Irene;Caldas, Carlos;Hayward, Nicholas K.;Pharoah, Paul D.;Fitzgerald, Rebecca C.;MacGregor, Stuart;Whiteman, David C.;Vaughan, Thomas L.
通讯作者：
Vaughan, Thomas L.