Updated recommendations for the diagnosis and management of osteoporosis: a local perspective.
Updated recommendations for the diagnosis and management of osteoporosis: a local perspective.
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DOI：
10.4103/0256-4947.77502
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发表时间：
2011-03
影响因子：
1.6
通讯作者：
King Faisal Specialist Hospital Osteoporosis Working Group
中科院分区：
文献类型：
--
作者：
Raef H;Al-Bugami M;Balharith S;Moawad M;El-Shaker M;Hassan A;Al-Shaikh A;Al-Badawi I;King Faisal Specialist Hospital Osteoporosis Working Group
绝经后骨质疏松症和老年男性骨质疏松症是主要的健康问题，具有显著的医疗和经济负担。虽然骨质减少和骨质疏松症在当地比西方国家更常见，但骨折率通常低于西方国家。维生素D缺乏症在该地区很常见，对骨骼健康有不利影响。维生素D缺乏症应怀疑和治疗所有受试者与骨质疏松症或骨质疏松症。使用危险因素来确定骨折风险已被世界卫生组织和许多国际社会所采用。绝对骨折风险方法通过针对骨折风险较高的受试者进行筛查和管理，改善了资源的使用。费萨尔国王专科医院骨质疏松症工作组建议对65岁及以上的妇女和70岁及以上的男子进行筛查。还应筛查有临床风险因素的年轻受试者和有骨质疏松症或导致骨质疏松症的疾病临床证据的人。这些指南提供了治疗绝经后妇女和50岁以上男性骨质疏松性骨折的建议，对于骨质疏松症患者（排除次要原因后）或低骨量和骨折高风险患者。工作组建议费萨尔国王专科医院采用一种算法，该算法基于各种治疗方式的可用性、成本和证据水平。建议所有人补充足够的钙和维生素D。每周一次的阿仑膦酸钠（在没有禁忌症的情况下）被推荐为一线治疗。阿仑膦酸钠的替代品是雷洛昔芬或雷奈酸锶。二线治疗是唑来膦酸静脉注射，每年一次，当口服治疗是不可行的或并发副作用，或特立哌齐在确定的骨质疏松症骨折。
Postmenopausal osteoporosis and osteoporosis in elderly men are major health problems, with a significant medical and economic burden. Although osteopenia and osteoporosis are more common locally than in the West, fracture rates are generally less than in Western countries. Vitamin D deficiency is common in the region and contributes adversely to bone health. Vitamin D deficiency should be suspected and treated in all subjects with ostopenia or osteoporosis. The use of risk factors to determine fracture risk has been adopted by the World Health Organization and many international societies. Absolute fracture risk methodology improves the use of resources by targeting subjects at higher risk of fractures for screening and management. The King Faisal Specialist Hospital Osteoporosis Working Group recommends screening for women 65 years and older and for men 70 years and older. Younger subjects with clinical risk factors and persons with clinical evidence of osteoporosis or diseases leading to osteoporosis should also be screened. These guidelines provide recommendations for treatment for postmenopausal women and men older than 50 years presenting with osteoporotic fractures for persons having osteoporosis—after excluding secondary causes—or for persons having low bone mass and a high risk for fracture. The Working Group has suggested an algorithm to use at King Faisal Specialist Hospital that is based on the availability, cost, and level of evidence of various therapeutic modalities. Adequate calcium and vitamin D supplement are recommended for all. Weekly alendronate (in the absence of contraindications) is recommended as first-line therapy. Alternatives to alendronate are raloxifene or strontium ranelate. Second-line therapies are zoledronic acid intravenously once yearly, when oral therapy is not feasible or complicated by side effects, or teriparatide in established osteoporosis with fractures.
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影响因子：
4
作者：
Boonen, S;Laan, RF;Watts, NB
通讯作者：
Watts, NB
DOI：
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发表时间：
2005-12-01
影响因子：
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