Cortical maturation and behavioral outcomes in children with auditory neuropathy spectrum disorder.
Cortical maturation and behavioral outcomes in children with auditory neuropathy spectrum disorder.
复制标题
听觉神经病谱系障碍儿童的皮质成熟和行为结果。
DOI：
10.3109/14992027.2010.542492
复制
发表时间：
2011-02
影响因子：
2.7
通讯作者：
Roland P
中科院分区：
文献类型：
--
作者：
Sharma A;Cardon G;Henion K;Roland P
听觉神经病谱系障碍（ANSD）影响近10%的感音神经性听力损失患者。虽然许多研究报告了ANSD儿童耳蜗、听神经和脑干水平的异常，但对他们的皮质发育知之甚少。我们检查了21名ANSD儿童的中枢听觉成熟。用皮层听觉诱发电位（CAEP）的形态学、潜伏期和波幅来评价听皮层的成熟度。儿童在听觉技能发展（IT-MAIS）方面的得分与CAEP相关。参与者是21名患有ANSD的儿童。他们都是助听器使用者。ANSD儿童表现出中枢听觉成熟的差异。总体而言，三分之二的儿童显示目前的P1 CAEP反应。其中，约三分之一（38%）显示正常的P1反应形态，潜伏期和振幅，而另外三分之一（33%）显示延迟P1反应潜伏期和显着较小的幅度。其余儿童（29%）显示异常或缺乏P1反应。总的来说，P1反应与听觉技能的发展显着相关。我们的研究结果表明，P1 CAEP反应可能是：（i）神经不同步破坏皮质发育的程度的一个有用的指标，（ii）ANSD儿童行为结果的一个很好的预测。
Auditory Neuropathy Spectrum Disorder (ANSD) affects nearly 10% of patients with sensorineural hearing loss. While many studies report abnormalities at the level of the cochlea, auditory nerve and brainstem in children with ANSD, much less is known about their cortical development. We examined central auditory maturation in 21 children with ANSD. Morphology, latency and amplitude of the P1 Cortical Auditory Evoked Potential (CAEP) were used to assess auditory cortical maturation. Children’s scores on a measure of auditory skill development (IT-MAIS) were correlated with CAEPs. Participants were 21 children with ANSD. All were hearing aid users. Children with ANSD exhibited differences in central auditory maturation. Overall, two-thirds of children revealed present P1 CAEP responses. Of these, approximately one third (38%) showed normal P1 response morphology, latency and amplitude, while another third (33%) showed delayed P1 response latencies and significantly smaller amplitudes. The remaining children (29%) revealed abnormal or absent P1 responses. Overall, P1 responses were significantly correlated with auditory skill development. Our results suggest that P1 CAEP responses may be: (i) a useful indicator of the extent to which neural dys-synchrony disrupts cortical development, (ii) a good predictor of behavioral outcome in children with ANSD.
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DOI：
10.1016/j.clinph.2009.05.013
发表时间：
2009-07
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Michalewski HJ;Starr A;Zeng FG;Dimitrijevic A
通讯作者：
Dimitrijevic A
影响因子：
2.9
作者：
Gilley, Phillip M.;Sharma, Anu;Dorman, Michael F.
通讯作者：
Dorman, Michael F.
DOI：
10.1001/archotol.128.9.1026
发表时间：
2002-09-01
影响因子：
--
作者：
Madden, C;Rutter, M;Choo, DI
通讯作者：
Choo, DI
影响因子：
4.7
作者：
Michalewski, HJ;Starr, A;Zeng, FG
通讯作者：
Zeng, FG
影响因子：
1.2
作者：
Pearce, Wendy;Golding, Maryanne;Dillon, Harvey
通讯作者：
Dillon, Harvey