Transmission Dynamics of Highly Pathogenic Avian Influenza Virus A(H5Nx) Clade 2.3.4.4, North America, 2014-2015.

Transmission Dynamics of Highly Pathogenic Avian Influenza Virus A(H5Nx) Clade 2.3.4.4, North America, 2014-2015.
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DOI:
10.3201/eid2410.171891
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发表时间:
2018-10
影响因子:
11.8
通讯作者:
Swayne DE
Swayne DE
中科院分区:
医学2区
文献类型:
--
作者:
Lee DH;Torchetti MK;Hicks J;Killian ML;Bahl J;Pantin-Jackwood M;Swayne DE

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欧亚高致病性禽流感病毒(HPAIV)H5分支2.3.4.4于2014年底在北美出现,并在2015年6月根除之前在美国造成影响5000万只家禽的疫情。我们通过使用268个全长基因组序列和暴发调查数据进行比较基因组研究,调查了与这种病毒传播相关的潜在生态和流行病学过程。在几次将病毒传播给家禽养殖场的溢出事件发生之前,重新配对的HPAIV H5N2在太平洋飞行路线上的野鸟中传播。我们的分析表明,2015年3月至6月期间,HPAIVH5N2单独传入中西部各州;太平洋野鸟传播到中西部家禽养殖场的情况发生在发现前1.7%至2.4月。≈;这种病毒一旦在家禽中传播,就会在火鸡和邻近各州的养鸡场之间迅速传播。需要加强生物安全,以防止HPAIV在整个家禽业的引入和传播。
Eurasia highly pathogenic avian influenza virus (HPAIV) H5 clade 2.3.4.4 emerged in North America at the end of 2014 and caused outbreaks affecting >50 million poultry in the United States before eradication in June 2015. We investigated the underlying ecologic and epidemiologic processes associated with this viral spread by performing a comparative genomic study using 268 full-length genome sequences and data from outbreak investigations. Reassortant HPAIV H5N2 circulated in wild birds along the Pacific flyway before several spillover events transmitting the virus to poultry farms. Our analysis suggests that >3 separate introductions of HPAIV H5N2 into Midwest states occurred during March–June 2015; transmission to Midwest poultry farms from Pacific wild birds occurred ≈1.7–2.4 months before detection. Once established in poultry, the virus rapidly spread between turkey and chicken farms in neighboring states. Enhanced biosecurity is required to prevent the introduction and dissemination of HPAIV across the poultry industry.
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