Changes in adaptation of H5N2 highly pathogenic avian influenza H5 clade 2.3.4.4 viruses in chickens and mallards.
Changes in adaptation of H5N2 highly pathogenic avian influenza H5 clade 2.3.4.4 viruses in chickens and mallards.
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DOI：
10.1016/j.virol.2016.08.036
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发表时间：
2016-12
期刊：
影响因子：
3.7
通讯作者：
Pantin-Jackwood, Mary J.
中科院分区：
文献类型：
--
作者：
DeJesus, Eric;Costa-Hurtado, Mar;Smith, Diane;Lee, Dong-Hun;Spackman, Erica;Kapczynski, Darrell R.;Torchetti, Mia Kim;Killian, Mary L.;Suarez, David L.;Swayne, David E.;Pantin-Jackwood, Mary J.
关键词：
2015 年，H5N2 高致病性禽流感 (HPAI) 病毒在美国引发了严重的家禽疫情。为了检查该病毒谱系的适应变化，我们在鸡和绿头鸭中研究了家禽 H5N2 病毒的感染性、发病机制和传播情况，并与野鸭 2014 年美国指数 H5N2 病毒进行了比较。检查的四种家禽分离株的平均鸟类感染剂量低于指示病毒，但向直接接触者的传播能力仍然较差。在绿头鸭中，两种 H5N2 家禽分离株与 H5N2 索引病毒、H5N8 美国索引病毒和 2005 年 H5N1 分支 2.2 病毒具有相似的高传染性和传播性。 H5N1 病毒导致死亡，有趣的是，两种家禽 H5N2 病毒分离株之一也导致死亡。家禽 H5N2 病毒观察到病毒对鸡的适应性增强；然而，这些病毒保留了对野鸭的高度适应性，但致病性受到不同程度的影响。
H5N2 highly pathogenic avian influenza (HPAI) viruses caused a severe poultry outbreak in the United States (U.S.) during 2015. In order to examine changes in adaptation of this viral lineage, the infectivity, pathogenesis and transmission of poultry H5N2 viruses were investigated in chickens and mallards in comparison to the wild duck 2014 U.S. index H5N2 virus. The four poultry isolates examined had a lower mean bird infectious dose than the index virus but still transmitted poorly to direct contacts. In mallards, two of the H5N2 poultry isolates had similar high infectivity and transmissibility as the index H5N2 virus, the H5N8 U.S. index virus, and a 2005 H5N1 clade 2.2 virus. Mortality occurred with the H5N1 virus and, interestingly, with one of two poultry H5N2 isolates. Increased virus adaptation to chickens was observed with the poultry H5N2 viruses; however these viruses retained high adaptation to mallards but pathogenicity was differently affected.
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影响因子：
4.6
作者：
Bevins SN;Dusek RJ;White CL;Gidlewski T;Bodenstein B;Mansfield KG;DeBruyn P;Kraege D;Rowan E;Gillin C;Thomas B;Chandler S;Baroch J;Schmit B;Grady MJ;Miller RS;Drew ML;Stopak S;Zscheile B;Bennett J;Sengl J;Brady C;Ip HS;Spackman E;Killian ML;Torchetti MK;Sleeman JM;Deliberto TJ
通讯作者：
Deliberto TJ
影响因子：
11.8
作者：
Brown JD;Stallknecht DE;Beck JR;Suarez DL;Swayne DE
通讯作者：
Swayne DE
影响因子：
3.7
作者：
Gilbert M;Jambal L;Karesh WB;Fine A;Shiilegdamba E;Dulam P;Sodnomdarjaa R;Ganzorig K;Batchuluun D;Tseveenmyadag N;Bolortuya P;Cardona CJ;Leung CY;Peiris JS;Spackman E;Swayne DE;Joly DO
通讯作者：
Joly DO
影响因子：
9.4
作者：
Spackman, E;Senne, DA;Suarez, DL
通讯作者：
Suarez, DL
影响因子：
2.4
作者：
Kwon, Y. K.;Thomas, C.;Swayne, D. E.
通讯作者：
Swayne, D. E.