The power of exercise: buffering the effect of chronic stress on telomere length.
The power of exercise: buffering the effect of chronic stress on telomere length.
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DOI：
10.1371/journal.pone.0010837
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发表时间：
2010-05-26
期刊：
影响因子：
3.7
通讯作者：
Epel E
中科院分区：
文献类型：
--
作者：
Puterman E;Lin J;Blackburn E;O'Donovan A;Adler N;Epel E
慢性心理压力与对身体健康的有害影响有关，并可能部分通过加速细胞衰老起作用，正如染色体末端较短的端粒所示。然而，并不是所有承受压力的人都有明显短的端粒，我们研究了运动是否能起到缓解压力的作用。我们预测慢性压力与久坐不动的人的端粒长度（TL）缩短有关，而在那些运动的人身上，压力对端粒缩短没有可测量的影响。采用定量聚合酶链反应法对63例健康绝经后妇女晨间空腹抽血进行全血TL分析。参与者完成了感知压力量表（Cohen et al., 1983），并连续三天报告每天的剧烈运动分钟数。参与者被分为两组——久坐不动和活跃（按照疾病控制中心推荐的每日活动量）。端粒长短的可能性被计算为压力和锻炼组、年龄、BMI和受教育程度共同变化的函数。逻辑回归分析显示运动有显著的调节作用。正如预测的那样，在非锻炼者中，感知压力量表每增加一个单位，端粒短的几率就会增加15倍（p< 0.05），而在锻炼者中，感知压力似乎与TL无关（B = -）。59、词义辨析：78, p = .45)。剧烈的体育活动似乎可以通过缓冲其与TL的关系来保护那些经历高压力的人。我们提出了体育活动可以缓冲压力效应的途径。
Chronic psychological stress is associated with detrimental effects on physical health, and may operate in part through accelerated cell aging, as indexed by shorter telomeres at the ends of chromosomes. However, not all people under stress have distinctly short telomeres, and we examined whether exercise can serve a stress-buffering function. We predicted that chronic stress would be related to short telomere length (TL) in sedentary individuals, whereas in those who exercise, stress would not have measurable effects on telomere shortening. 63 healthy post-menopausal women underwent a fasting morning blood draw for whole blood TL analysis by a quantitative polymerase chain reaction method. Participants completed the Perceived Stress Scale (Cohen et al., 1983), and for three successive days reported daily minutes of vigorous activity. Participants were categorized into two groups-sedentary and active (those getting Centers for Disease Control-recommended daily amount of activity). The likelihood of having short versus long telomeres was calculated as a function of stress and exercise group, covarying age, BMI and education. Logistic regression analyses revealed a significant moderating effect of exercise. As predicted, among non-exercisers a one unit increase in the Perceived Stress Scale was related to a 15-fold increase in the odds of having short telomeres (p<.05), whereas in exercisers, perceived stress appears to be unrelated to TL (B = −.59, SE = .78, p = .45). Vigorous physical activity appears to protect those experiencing high stress by buffering its relationship with TL. We propose pathways through which physical activity acts to buffer stress effects.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
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