Insights of roles played by septins in pathogenic fungi.

Insights of roles played by septins in pathogenic fungi.
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DOI:
10.1080/21505594.2021.1933370
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发表时间:
2021-12
期刊:
影响因子:
5.2
通讯作者:
Lin FC
Lin FC
中科院分区:
生物学2区
文献类型:
--
作者:
Li L;Zhu XM;Su ZZ;Del Poeta M;Liu XH;Lin FC

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Septins是一类保守的GTP结合蛋白家族,在真核生物的细胞分裂、极性和膜重塑等过程中发挥重要作用,是细胞骨架的重要组成部分。尽管septins在模式生物酿酒酵母(Saccharomycescerevisiae)中所起的作用已被确定,但它们在其他真菌,特别是致病真菌中的重要性最近已被确定。本文综述了近两年来有关septins在病原真菌细胞周期、自噬、内吞和入侵宿主-微生物相互作用等方面的研究进展。这些新的发现可能会扩大到研究septin蛋白在真菌发病机制中的功能,并可能会引起《微生物学和分子病理学》读者的广泛兴趣。
Septins, a conserved family of GTP-binding proteins, are widely recognized as an essential cytoskeletal component, playing important roles in a variety of biological processes, including division, polarity, and membrane remodeling, in different eukaryotes. Although the roles played by septins were identified in the model organism Saccharomyces cerevisiae, their importance in other fungi, especially pathogenic fungi, have recently been determined. In this review, we summarize the functions of septins in pathogenic fungi in the cell cycle, autophagy, endocytosis and invasion host-microbe interactions that were reported in the last two years in the field of septin cell biology. These new discoveries may be expanded to investigate the functions of septin proteins in fungal pathogenesis and may be of wide interest to the readers of Microbiology and Molecular Pathology.
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发表时间: 1976-06
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