An Examination of Donor Factors That Impact the Results of the Glucagon Stimulation Test as an Assessment of the Pancreatic Graft Endocrine Function
An Examination of Donor Factors That Impact the Results of the Glucagon Stimulation Test as an Assessment of the Pancreatic Graft Endocrine Function
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检查影响胰高血糖素刺激试验结果的供体因素作为胰腺移植物内分泌功能的评估
DOI：
10.1097/mpa.0000000000002093
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发表时间：
2022
期刊：
影响因子：
2.9
通讯作者：
Shintani Ayumi
中科院分区：
文献类型：
--
作者：
Ito Taihei;Kenmochi Takashi;Aida Naohiro;Hiratsuka Izumi;Matsushima Hajime;Kurihara Kei;Suzuki Atsushi;Shibata Megumi;Kusaka Mamoru;Hasegawa Midori;Ishihara Takuma;Go Hirofumi;Yabusaki Kohei;Shintani Ayumi
目的胰升糖素刺激试验所得的Delta C肽是评价胰腺移植术后胰腺内分泌功能的可靠指标。我们研究了作为移植胰腺内分泌功能的增量C-肽与供体背景因素的关系。结果年龄在50岁或以上、死于脑血管意外、血红蛋白A1c水平在5.6%或以上、肌酐水平在1.0 mg/dL或以上、C反应蛋白水平在25 mg/dL或以上、钠水平在150 mmol/L或以上与移植后移植胰腺的内分泌功能显著恶化有关。此外，这些供体因子数量的增加表明移植后胰腺内分泌功能的恶化程度显著增加(P<；0.001)。结论为了确保胰腺移植后胰岛素的独立性，即在胰升糖素刺激试验中将增量C肽水平维持在1.0 ng/mL或更高，应仔细考虑拥有本研究确定的供体因子中3个以上的供体的使用。
ObjectivesDelta C-peptide derived by the glucagon stimulation test is a reliable value for the evaluation of the pancreatic endocrine function after pancreas transplantation. We examined the associations between delta C-peptide as pancreatic graft endocrine function and donor background factors.MethodsSixty-five cases of pancreatic transplantation from brain-dead donors, which were performed in our facility, were enrolled in this study. Enrolled recipients underwent a glucagon stimulation test within 1 to 3 months after transplantation to evaluate the pancreatic graft endocrine function with delta C-peptide to compare donor background factors.ResultsThe following factors were associated with significant deterioration of the delta C-peptide: age of 50 years or greater, death from cerebrovascular accident, hemoglobin A1c level of 5.6% or greater, creatinine level of 1.0 mg/dL or greater, C-reactive protein level of 25 mg/dL or greater, and sodium level of 150 mmol/L or greater. In addition, increased numbers of these donor factors indicated significantly greater deterioration of the posttransplant pancreatic endocrine function (P< 0.001).ConclusionsTo secure insulin independence after pancreas transplantation, which means maintaining a delta C-peptide level of 1.0 ng/mL or greater on a glucagon stimulation test, the utilization of donors, who possesses more than equal to 3 of the donor factors identified in this study, should be carefully considered.
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影响因子：
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影响因子：
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