Quantitative 3D Ultrashort Echo Time Magnetization Transfer Imaging for Evaluation of Knee Cartilage Degeneration In Vivo.
Quantitative 3D Ultrashort Echo Time Magnetization Transfer Imaging for Evaluation of Knee Cartilage Degeneration In Vivo.
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DOI：
10.1002/jmri.27659
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发表时间：
2021-10
影响因子：
4.4
通讯作者：
Du, Jiang
中科院分区：
文献类型：
--
作者：
Xue, Yan-Ping;Ma, Ya-Jun;Wu, Mei;Jerban, Saeed;Wei, Zhao;Chang, Eric Y.;Du, Jiang
最近的研究表明，源自 3D 超短回波时间磁化转移 (UTE-MT) 成像的大分子分数 (MMF) 对魔角效应不敏感。然而，其在骨关节炎（OA）中的临床应用仍有待研究。研究 3D UTE-MT 衍生的 MMF 区分正常软骨和退化软骨的可行性。预期。 62 名患有或不患有 OA 的参与者（54.8±16.7 岁，30 名女性），加上两名健康志愿者（平均年龄 35.0 岁）进行重复性测试。 3T/UTE-MT 序列。采用 3D UTE-MT 序列来计算基于两池模型的 MMF。 Kellgren–Lawrence (KL) 分级和全器官磁共振成像评分 (WORMS) 由三位经验丰富的肌肉骨骼放射科医生进行评估。 KL 等级分为三组：KL0、KL1-2 和 KL3-4。分别根据病变范围（范围组）和病变深度（深度组）对 WORMS 进行重新分组。通过 Spearman 相关系数和根据接受者操作特征 (ROC) 曲线计算的曲线下面积 (AUC) 来评估 MMF 在评估软骨退变方面的性能。正态性检查后，使用单向方差分析（ANOVA）来评估性能。进行 Tukey-Kramer 测试以进行事后测试。 MMF与KL等级（r=-0.53，P<0.05）和WORMS（r=-0.49，P<0.05）呈显着负相关。 KL 等级较高的受试者（KL0 为 11.8±0.8%；KL1-2 为 10.9±0.9%；KL3-4 为 10.6±1.1%；P<0.05）和软骨范围较大的受试者（正常软骨为 12.1±1.6%；区域病变为 10.9±1.6%；弥漫性病变为9.6±1.7%；P<0.05）和病变深度（正常软骨为12.1±1.6%；部分厚度病变为10.6±1.6%；全层病变为8.8±1.7%；P<0.05）。可疑最小 OA (KL1-2) 和轻度软骨退化 (WORMS1-2) 的 MMF AUC 值分别为 0.8 和 0.7。这项研究强调了 MMF 在检测早期 OA 方面的临床潜力。
Recent studies suggest that macromolecular fraction (MMF) derived from 3D ultrashort echo time magnetization transfer (UTE-MT) imaging is insensitive to the magic angle effect. However, its clinical use in osteoarthritis (OA) remains to be investigated. To investigate the feasibility of 3D UTE-MT-derived MMF in differentiating normal from degenerated cartilage. Prospective. 62 participants (54.8±16.7 years, 30 females) with and without OA, plus two healthy volunteers (mean age 35.0 years) for reproducibility test. 3T/UTE-MT sequence. A 3D UTE-MT sequence was employed to calculate MMF based on a two-pool model. Kellgren–Lawrence (KL) grade and Whole-Organ Magnetic Resonance Imaging Score (WORMS) were evaluated by three experienced musculoskeletal radiologists. KL grade was condensed into three groups: KL0, KL1-2, and KL3-4. WORMS was regrouped based on extent of lesion (extent group) and depth of lesion (depth group), respectively. The performance of MMF at evaluating the degeneration of cartilage was assessed via Spearman’s correlation coefficient and the area under the curve (AUC) calculated according to the receiver-operating characteristic (ROC) curve. After normality check, one-way analysis of variance (ANOVA) was used to evaluate the performance. Tukey-Kramer test was performed for post-hoc testing. MMF showed significant negative correlations with KL grade (r=−0.53, P<0.05) and WORMS (r=−0.49, P<0.05). Significantly lower MMFs were found in subjects with greater KL grade (11.8±0.8% for KL0; 10.9±0.9% for KL1-2; 10.6±1.1% for KL3-4; P<0.05) and in cartilage with greater extent (12.1±1.6% for normal cartilage; 10.9±1.6% for regional lesions; 9.6±1.7% for diffuse lesions; P<0.05) and depth (12.1±1.6% for normal cartilage; 10.6±1.6% for partial-thickness lesions; 8.8±1.7% for full-thickness lesions; P<0.05) of lesions. AUC values of MMF for doubtful-minimal OA (KL1-2) and mild cartilage degradation (WORMS1-2) were 0.8 and 0.7, respectively. This study highlights the clinical potential of MMF in the detection of early OA.
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关节软骨 T2 松弛的 UTE 双成分分析
影响因子：
7
作者：
Shao H;Chang EY;Pauli C;Zanganeh S;Bae W;Chung CB;Tang G;Du J
通讯作者：
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影响因子：
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作者：
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Chu, Constance R.
影响因子：
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作者：
Su, F.;Hilton, J. F.;Nardo, L.;Wu, S.;Liang, F.;Link, T. M.;Ma, C. B.;Li, X.
通讯作者：
Li, X.
影响因子：
19.7
作者：
Link, TM;Steinbach, LS;Majumdar, S
通讯作者：
Majumdar, S