Association of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with knee pain: data from the Osteoarthritis Initiative.
Association of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with knee pain: data from the Osteoarthritis Initiative.
复制标题
DOI：
10.1002/acr.20672
复制
发表时间：
2012-02
影响因子：
4.7
通讯作者：
Link, Thomas M.
中科院分区：
文献类型：
--
作者：
Baum, Thomas;Joseph, Gabby B.;Arulanandan, Ahilan;Nardo, Lorenzo;Virayavanich, Warapat;Carballido-Gamio, Julio;Nevitt, Michael C.;Lynch, John;McCulloch, Charles E.;Link, Thomas M.
在有骨关节炎（OA）风险因素的受试者中，评价基于MRI的膝关节软骨T2测量值和局灶性膝关节病变与无放射学骨关节炎（OA）膝关节疼痛的相关性。我们研究了来自骨关节炎倡议数据库的126名受试者的右膝。我们随机选择了42名年龄在45-55岁之间的受试者，这些受试者具有OA风险因素，右膝疼痛（WOMAC疼痛评分≥5），无左膝疼痛（WOMAC疼痛评分=0），右膝无放射学OA（KL评分≤1）。我们还选择了两个对照组：42名受试者没有膝关节疼痛，在任何一个膝盖和42名双侧膝关节疼痛。根据性别、年龄、BMI和KL评分，两组均与仅右膝疼痛的受试者频率匹配。所有受试者均接受右膝3 T MRI检查。评估膝关节局灶性病变，并进行软骨T2测量。两组之间的膝关节、骨髓和韧带病变以及关节积液的患病率没有显著差异（p>0.05），而与没有膝关节疼痛的受试者相比，仅右侧膝关节疼痛的受试者中软骨病变更常见（p<0.05）。仅右侧膝关节疼痛（34.4±1.8ms）和双侧膝关节疼痛（34.7±4.7ms）受试者的所有室的平均T2值相似，但显著高于无膝关节疼痛的受试者（32.4±1.8ms）（p<0.05）。这些结果表明，软骨T2值升高与OA早期疼痛的发现相关，而在形态学膝关节异常中，只有膝关节软骨病变与膝关节疼痛状态显著相关。
To evaluate the association of MRI-based knee cartilage T2 measurements and focal knee lesions with knee pain in knees without radiographic osteoarthritis (OA) among subjects with OA risk factors. We studied the right knees of 126 subjects from the Osteoarthritis Initiative database. We randomly selected 42 subjects aged 45–55 years with OA risk factors, right knee pain (WOMAC pain score ≥5), no left knee pain (WOMAC pain score =0) and no radiographic OA (KL-score ≤1) in the right knee. We also selected two comparison groups: 42 subjects without knee pain in either knee and 42 with bilateral knee pain. Both groups were frequency matched to subjects with right knee only pain by gender, age, BMI and KL-score. All subjects underwent 3T MRI of the right knee. Focal knee lesions were assessed and cartilage T2 measurements were performed. Prevalence of meniscal, bone marrow and ligamentous lesions and joint effusion were not significantly different between the groups (p>0.05), while cartilage lesions were more frequent in subjects with right only knee pain compared to subjects without knee pain (p<0.05). T2 values averaged over all compartments were similar in subjects with right only knee pain (34.4±1.8ms) and with bilateral knee pain (34.7±4.7ms), but significantly higher compared to subjects without knee pain (32.4±1.8ms) (p<0.05). These results suggest that elevated cartilage T2 values are associated with findings of pain in the early phase of OA, while among morphological knee abnormalities only knee cartilage lesions are significantly associated with knee pain status.
登录
查看更多内容
影响因子：
--
作者：
Moisio, Kirsten;Eckstein, Felix;Chmiel, Joan S.;Guermazi, Ali;Prasad, Pottumarthi;Almagor, Orit;Song, Jing;Dunlop, Dorothy;Hudelmaier, Martin;Kothari, Ami;Sharma, Leena
通讯作者：
Sharma, Leena
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick
影响因子：
5.9
作者：
Friedrich, Klaus M.;Shepard, Timothy;Regatte, Ravinder
通讯作者：
Regatte, Ravinder
影响因子：
2.3
作者：
Hunter, David J.;McDougall, Jason J.;Keefe, Francis J.
通讯作者：
Keefe, Francis J.
影响因子：
7
作者：
Peterfy CG;Schneider E;Nevitt M
通讯作者：
Nevitt M