COVID-KOP: integrating emerging COVID-19 data with the ROBOKOP database.

COVID-KOP: integrating emerging COVID-19 data with the ROBOKOP database.
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DOI:
10.1093/bioinformatics/btaa718
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发表时间:
2021-05-01
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
通讯作者:
Tropsha A
Tropsha A
中科院分区:
其他
文献类型:
--
作者:
Korn D;Bobrowski T;Li M;Kebede Y;Wang P;Owen P;Vaidya G;Muratov E;Chirkova R;Bizon C;Tropsha A

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为应对COVID-19大流行,我们建立了COVID-KOP,这是一个新的知识库,整合了现有的以知识导向路径(ROBOKOP)链接的生物医学对象推理生物医学知识图,以及CORD-19集合中注释的最新COVID-19生物医学文献的信息。COVID-KOP可以有效地用于通过建立各自的药物作用的确证性途径来产生关于针对COVID-19的已知药物和临床候选药物的再利用的新假设。COVID-KOP可在https://covidkop.renci.org/上免费访问。有关原始ROBOKOP的代码和说明,请参阅:https://github.com/NCATS-Gamma/robokop。
In response to the COVID-19 pandemic, we established COVID-KOP, a new knowledgebase integrating the existing Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP) biomedical knowledge graph with information from recent biomedical literature on COVID-19 annotated in the CORD-19 collection. COVID-KOP can be used effectively to generate new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID-19 by establishing respective confirmatory pathways of drug action. COVID-KOP is freely accessible at https://covidkop.renci.org/. For code and instructions for the original ROBOKOP, see: https://github.com/NCATS-Gamma/robokop.
DOI: 10.1371/journal.ppat.1002660
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