Infusion of etoposide in the CA1 disrupts hippocampal immediate early gene expression and hippocampus-dependent learning.
Infusion of etoposide in the CA1 disrupts hippocampal immediate early gene expression and hippocampus-dependent learning.
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DOI：
10.1038/s41598-022-17052-y
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发表时间：
2022-07-27
影响因子：
4.6
通讯作者：
Raber, Jacob
中科院分区：
文献类型：
--
作者：
Boutros, Sydney Weber;Kessler, Kat;Unni, Vivek K.;Raber, Jacob
Tight regulation of immediate early gene (IEG) expression is important for synaptic plasticity, learning, and memory. Recent work has suggested that DNA double strand breaks (DSBs) may have an adaptive role in post-mitotic cells to induce IEG expression. Physiological activity in cultured neurons as well as behavioral training leads to increased DSBs and subsequent IEG expression. Additionally, infusion of etoposide—a common cancer treatment that induces DSBs—impairs trace fear memory. Here, we assessed the effects of hippocampal infusion of 60 ng of etoposide on IEG expression, learning, and memory in 3–4 month-old C57Bl/6J mice. Etoposide altered expression of the immediate early genes cFos and Arc in the hippocampus and impaired hippocampus-dependent contextual fear memory. These data add to the growing evidence that DSBs play an important role in IEG expression, learning, and memory, opening avenues for developing novel treatment strategies for memory-related disorders.
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DOI：
10.1016/0169-328x(93)90012-e
发表时间：
1993-03-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
DEMMER, J;DRAGUNOW, M;TATE, WP
通讯作者：
TATE, WP
乳腺癌幸存者静息态海马功能网络的改变与化疗引起的前瞻性记忆损伤相关
影响因子：
4.6
作者：
Cheng H;Li W;Gong L;Xuan H;Huang Z;Zhao H;Wang LS;Wang K
通讯作者：
Wang K
影响因子：
15.1
作者：
Kempf SJ;Casciati A;Buratovic S;Janik D;von Toerne C;Ueffing M;Neff F;Moertl S;Stenerlöw B;Saran A;Atkinson MJ;Eriksson P;Pazzaglia S;Tapio S
通讯作者：
Tapio S
影响因子：
2.7
作者：
Heroux NA;Osborne BF;Miller LA;Kawan M;Buban KN;Rosen JB;Stanton ME
通讯作者：
Stanton ME
影响因子：
--
作者：
Boutros SW;Krenik D;Holden S;Unni VK;Raber J
通讯作者：
Raber J