Does smoking have an impact on the immunological response to COVID-19 vaccines? Evidence from the VASCO study and need for further studies.
Does smoking have an impact on the immunological response to COVID-19 vaccines? Evidence from the VASCO study and need for further studies.
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DOI：
10.1016/j.puhe.2021.12.013
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发表时间：
2022-03
期刊：
影响因子：
5.2
通讯作者：
Polosa R
中科院分区：
文献类型：
--
作者：
Ferrara P;Ponticelli D;Agüero F;Caci G;Vitale A;Borrelli M;Schiavone B;Antonazzo IC;Mantovani LG;Tomaselli V;Polosa R
本研究的目的是研究吸烟对BNT162b2 mRNA COVID-19疫苗（也称为BioNTech-Pfizer COVID-19疫苗）的体液反应的可能影响。在意大利卫生保健工作者（HCWs）样本中进行了纵向血清流行病学研究。在2020年12月至2021年1月期间间隔21天接种两剂BNT162b2 mRNA疫苗的卫生保健工作者被邀请进行多次血清学检测，以鉴定SARS-CoV-2 s - rbd特异性免疫球蛋白G （IgG）抗体。参与者还在一项调查中回答了有关他们吸烟状况的问题（即当前吸烟者与不吸烟者）。接种周期结束后60天，血清学分析显示，当前吸烟者和非吸烟者之间疫苗诱导的IgG滴度存在差异，抗体滴度中位数分别为211.80 AU/mL（四分位间距[IQR] 149.80-465.50）和487.50 AU/mL（四分位间距[IQR] 308.45-791.65） [p值= 0.002]。在调整了年龄、性别和既往SARS-CoV-2感染后，当前吸烟者和非吸烟者之间疫苗诱导的IgG滴度的显著差异仍然存在。本研究发现，当前吸烟者中疫苗诱导的抗体滴度比不吸烟者下降得更快。需要进一步研究吸烟对COVID-19和非COVID-19疫苗免疫反应的影响。
The aim of this study was to investigate the possible impact of smoking on the humoral response to the BNT162b2 mRNA COVID-19 vaccine (also known as the BioNTech-Pfizer COVID-19 vaccine). A longitudinal sero-epidemiological study was conducted in sample of Italian healthcare workers (HCWs). HCWs who were administered two doses of the BNT162b2 mRNA vaccine, 21 days apart, between December 2020 and January 2021, were invited to undergo multiple serology tests to identify SARS-CoV-2 S-RBD-specific immunoglobulin G (IgG) antibodies. Participants also responded to questions about their smoking status (i.e. current smokers vs non-smokers) in a survey. Sixty days after the completion of the vaccination cycle, serological analyses showed a difference in vaccine-induced IgG titre between current smokers and non-smokers, with median antibody titres of 211.80 AU/mL (interquartile range [IQR] 149.80–465.50) and 487.50 AU/mL (IQR 308.45–791.65) [P-value = 0.002], respectively. This significant difference in vaccine-induced IgG titres between current smokers and non-smokers remained after adjusting for age, sex, and previous infection with SARS-CoV-2. This study observed that vaccine-induced antibody titres decrease faster among current smokers than non-smokers. Further research to investigate the impact of smoking on the immunological response to COVID-19 and non-COVID-19 vaccines is required.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1161/atvbaha.118.312338
发表时间：
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影响因子：
8.7
作者：
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通讯作者：
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影响因子：
4.6
作者：
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通讯作者：
Mantovani LG