Importance of integrin LFA-1 deactivation for the generation of immune responses.
Importance of integrin LFA-1 deactivation for the generation of immune responses.
复制标题
整联蛋白LFA-1失活对于产生免疫反应的重要性。
DOI：
10.1084/jem.20041850
复制
发表时间：
2005-06-20
影响因子：
15.3
通讯作者：
Holzmann, B
中科院分区：
文献类型：
--
作者：
Semmrich, M;Smith, A;Feterowski, C;Beer, S;Engelhardt, B;Busch, DH;Bartsch, B;Laschinger, M;Hogg, N;Pfeffer, K;Holzmann, B
The dynamic regulation of ligand binding is considered crucial for integrin function. However, the importance of activity regulation for integrin function in vivo is largely unknown. Here, we have applied gene targeting to delete the GFFKR sequence of the lymphocyte function-associated antigen–1 (LFA-1) αL subunit cytoplasmic domain in mouse germline. Lymphocytes from Lfa-1 d/d mutant mice showed constitutive activation of LFA-1–mediated cell adhesion and impaired de-adhesion from intercellular adhesion molecule-1 that resulted in defective cell migration. In contrast, signaling through LFA-1 was not affected in Lfa-1 d/d cells. T cell activation by superantigen-loaded and allogeneic APCs, cytotoxic T cell activity, T-dependent humoral immune responses, and neutrophil recruitment during aseptic peritonitis were impaired in Lfa-1 d/d mice. Thus, deactivation of LFA-1 and disassembly of LFA-1–mediated cell contacts seem to be vital for the generation of normal immune responses.
登录
查看更多内容
影响因子：
56.9
作者：
Garside, P;Ingulli, E;Jenkins, MK
通讯作者：
Jenkins, MK
影响因子：
46.9
作者：
Cho, HJ;Takabayashi, K;Raz, E
通讯作者：
Raz, E
影响因子：
30.5
作者：
Perez, OD;Mitchell, D;Nolan, GP
通讯作者：
Nolan, GP
影响因子：
56.9
作者：
Laudanna, C;Campbell, JJ;Butcher, EC
通讯作者：
Butcher, EC
影响因子：
56.9
作者：
Kim, M;Carman, CV;Springer, TA
通讯作者：
Springer, TA