Cardiovascular Risk Factors and Their Relationship with Vascular Dysfunction in South African Children of African Ancestry.
Cardiovascular Risk Factors and Their Relationship with Vascular Dysfunction in South African Children of African Ancestry.
复制标题
DOI：
10.3390/jcm10020354
复制
发表时间：
2021-01-19
影响因子：
3.9
通讯作者：
Goswami N
中科院分区：
文献类型：
--
作者：
Matjuda EN;Engwa GA;Anye SNC;Nkeh-Chungag BN;Goswami N
已知血管功能障碍是心血管疾病（CVD）的发展和进展的引发剂。然而，在非洲血统的儿童中，血管功能障碍与心血管危险因素之间的关系的信息很少。本研究调查了南非非洲裔儿童心血管危险因素与血管功能之间的关系。对南非东开普省随机选择的农村和城市学校的6-9岁儿童进行了横断面研究。测量一般人体测量指标，然后测量血压（BP）。脉搏波传导速度（PWV）使用Vicorder测量。测定尿白蛋白/肌酐比值（ACR）、不对称二甲基精氨酸（ADMA）、8-羟基脱氧鸟苷（8-OHdG）和硫代巴比妥酸反应物（TBARS）。城市儿童（10.8%）超重/肥胖的患病率高于农村儿童（8.5%），而农村儿童（23.2%）血压升高/高血压的患病率高于城市儿童（19.0%）。平均动脉压（MAP）和舒张压（DBP）随PWV的增加而升高（p < 0.05）。体重指数（BMI）、舒张压（DBP）、平均动脉压（MAP）与PWV呈正相关（p < 0.05）。肌酐、白蛋白和ACR随ADMA增加而显著增加（p < 0.005）。ADMA与肌酐和8-OHdG呈正相关（p < 0.05）。总之，血管功能障碍与南非非洲裔儿童的肥胖、高血压、氧化应激和微量白蛋白尿有关。
Vascular dysfunction is known to be an initiator of the development and progression of cardiovascular diseases (CVDs). However, there is paucity of information on the relationship of vascular dysfunction with cardiovascular risk factors in children of African ancestry. This study investigated the relationship between cardiovascular risk factors and vascular function in South African children of African ancestry. A cross-sectional study on 6–9-year-old children in randomly selected rural and urban schools of the Eastern Cape Province of South Africa was conducted. General anthropometric indices were measured, followed by blood pressure (BP) measurements. The pulse wave velocity (PWV) was measured using a Vicorder. Albumin to creatinine ratio (ACR), asymmetric dimethylarginine (ADMA), 8-hydroxy-2deoxyguanosine (8-OHdG) and thiobarbituric acid reactive substance (TBARS) were assayed in urine. Children from urban settings (10.8%) had a higher prevalence of overweight/obesity than their rural counterparts (8.5%) while the prevalence of elevated/high blood pressure was higher in rural (23.2%) than urban children (19.0%). Mean arterial blood pressure (MAP) and diastolic blood pressure (DBP) increased with increasing PWV (p < 0.05). Body mass index (BMI), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) positively associated (p < 0.05) with PWV. Creatinine, albumin and ACR significantly (p < 0.005) increased with increasing ADMA. ADMA associated positively (p < 0.05) with creatinine and 8-OHdG. In conclusion, vascular dysfunction was associated with obesity, high blood pressure, oxidative stress and microalbuminuria in South African children of African ancestry.
登录
查看更多内容
DOI：
10.1161/atvbaha.116.308749
发表时间：
2017-03
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Den Hartigh LJ;Omer M;Goodspeed L;Wang S;Wietecha T;O'Brien KD;Han CY
通讯作者：
Han CY
DOI：
10.1053/j.ajkd.2017.12.013
发表时间：
2018-08
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Jotwani V;Katz R;Ix JH;Gutiérrez OM;Bennett M;Parikh CR;Cummings SR;Sarnak MJ;Shlipak MG
通讯作者：
Shlipak MG
影响因子：
7.4
作者：
Hensley, K;Robinson, KA;Floyd, RA
通讯作者：
Floyd, RA
影响因子：
2.8
作者：
Kulsum-Mecci, Nazia;Goss, Charles;Dharnidharka, Vikas R.
通讯作者：
Dharnidharka, Vikas R.
影响因子：
1.7
作者：
Guilherme, Flávio Ricardo;Molena-Fernandes, Carlos Alexandre;Rinaldi, Wilson
通讯作者：
Rinaldi, Wilson