Changes of Hypothalamic GnRH-I, POMC and NPY mRNA Expression and Serum IGF-I and Leptin Concentrations during Maturation of Shaoxing Ducks (Anas platyrhynchos)
Changes of Hypothalamic GnRH-I, POMC and NPY mRNA Expression and Serum IGF-I and Leptin Concentrations during Maturation of Shaoxing Ducks (Anas platyrhynchos)
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绍兴鸭成熟过程中下丘脑GnRH-I、POMC、NPY mRNA表达及血清IGF-I、瘦素浓度的变化
DOI：
10.5713/ajas.2011.11024
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Lu, L.
中科院分区：
文献类型：
--
作者：
Ni, Y.;Zhao, R.;Chen, J.;Lu, L.
Sexual maturity in poultry is controlled by a complex neural circuit located in the basal forebrain, which integrates the central and peripheral signals to activate hypothalamic gonadotrophin-releasing hormone (GnRH) secretion. This study demonstrated the changes of GnRH-I, POMC and NPY mRNA transcription in hypothalamus and IGF-I and leptin levels in serum of Shaoxing ducks during puberty. Body weight increased progressively from d30 to d120 and at d120 the flock reached 5% of laying rate. A significant up- regulation of hypothalamic GnRH-I mRNA expression was observed from d60, reaching the peak at d120. POMC and NPY mRNA expression in hypothalamus showed a similar pattern, which increased from d30 to d60, followed by a significant decrease towards sexual maturity. Serum IGF-I levels exhibited two peaks at d30 and d120, respectively. Serum leptin displayed a single peak at d90. The results indicate that the down-regulation of POMC and NPY genes in hypothalamus coincides with the up-regulation of GnRH-I gene to initiate sexual maturation in ducks. In addition, peripheral IGF-I and leptin may relay the peripheral metabolic status to the central system and contribute to the initiation of the reproductive function in ducks. (Key Words : GnRH-I, POMC, NPY, Leptin, IGF-1, Sexual Maturity, Duck)
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影响因子：
56.9
作者：
Chehab, FF;Mounzih, K;Lim, ME
通讯作者：
Lim, ME
DOI：
10.1073/pnas.090099697
发表时间：
2000-05
影响因子：
11.1
作者：
M. Majdoubi;A. Sahu;S. Ramaswamy;T. Plant
通讯作者：
M. Majdoubi;A. Sahu;S. Ramaswamy;T. Plant
DOI：
10.1677/joe.0.1140103
发表时间：
1987-07
期刊：
The Journal of endocrinology
影响因子：
--
作者：
S. Stansfield;F. J. Cunningham
通讯作者：
S. Stansfield;F. J. Cunningham
影响因子：
4.8
作者：
Barash, IA;Cheung, CC;Steiner, RA
通讯作者：
Steiner, RA
DOI：
10.1111/j.1749-6632.2000.tb06210.x
发表时间：
2000-04
影响因子：
5.2
作者：
A. Genazzani;F. Bernardi;P. Monteleone;S. Luisi;M. Luisi
通讯作者：
A. Genazzani;F. Bernardi;P. Monteleone;S. Luisi;M. Luisi