Therapeutic Delivery of Nitric Oxide Utilizing Saccharide-Based Materials.
Therapeutic Delivery of Nitric Oxide Utilizing Saccharide-Based Materials.
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DOI：
10.1021/acsami.1c10964
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发表时间：
2021-11-10
影响因子：
9.5
通讯作者：
Brisbois, Elizabeth J.
中科院分区：
文献类型：
--
作者：
Qian, Yun;Kumar, Rajnish;Chug, Manjyot Kaur;Massoumi, Hamed;Brisbois, Elizabeth J.
作为气体递质，一氧化氮（NO）调节生理途径并显示治疗作用，如血管舒张、抗炎、抗血小板、抗血栓形成、抗菌和抗病毒特性。然而，气态NO反应活性高，半衰期短，因此NO的输送和储存是一个亟待解决的问题。一种方法是开发稳定的NO供体，另一种方法是增强生物材料中NO供体的递送和储存。大多数研究NO释放和应用的研究人员都使用合成聚合物材料，并且他们已经证明这些释放NO的聚合物材料对心血管疾病，呼吸系统疾病，细菌感染等具有显着的治疗效果。然而，一些研究人员正在探索糖基材料，以实现与合成对应物相同的任务，同时避免生物相容性，生物降解性，和可持续性。糖基材料在自然界中含量丰富，具有生物相容性和可生物降解性，在生物工程、药物输送和疾病治疗等领域有着广泛的应用。已经通过化学和物理方法用各种NO供体（如S-亚硝基硫醇和N-二醇二氮烯鎓）实现了基于糖的材料以递送NO。这些释放NO的基于糖的材料已经表现出受控和持续的NO释放，并在各种疾病（呼吸系统、克罗恩病、心血管等）中显示出生物医学应用，皮肤或伤口应用、抗菌治疗、骨再生、抗凝以及农业和食品包装。本文综述了糖基NO释放材料的研究方法和进展，并探讨了糖基NO释放材料在生物医学、生物工程和疾病治疗中的应用前景。
As a gasotransmitter, nitric oxide (NO) regulates physiological pathways and demonstrates therapeutic effects such as vascular relaxation, anti-inflammation, antiplatelet, antithrombosis, antibacterial, and antiviral properties. However, gaseous NO has high reactivity and a short half-life, so NO delivery and storage are critical questions to be solved. One way is to develop stable NO donors and the other way is to enhance the delivery and storage of NO donors from biomaterials. Most of the researchers studying NO delivery and applications are using synthetic polymeric materials, and they have demonstrated significant therapeutic effects of these NO-releasing polymeric materials on cardiovascular diseases, respiratory disease, bacterial infections, etc. However, some researchers are exploring saccharide-based materials to fulfill the same tasks as their synthetic counterparts while avoiding the concerns of biocompatibility, biodegradability, and sustainability. Saccharide-based materials are abundant in nature and are biocompatible and biodegradable, with wide applications in bioengineering, drug delivery, and therapeutic disease treatments. Saccharide-based materials have been implemented with various NO donors (like S-nitrosothiols and N-diazeniumdiolates) via both chemical and physical methods to deliver NO. These NO-releasing saccharide-based materials have exhibited controlled and sustained NO release and demonstrated biomedical applications in various diseases (respiratory, Crohn’s, cardiovascular, etc.), skin or wound applications, antimicrobial treatment, bone regeneration, anticoagulation, as well as agricultural and food packaging. This review aims to highlight the studies in methods and progress in developing saccharide-based NO-releasing materials and investigating their potential applications in biomedical, bioengineering, and disease treatment.
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