Hazard of incident and progressive knee and hip radiographic osteoarthritis and chronic joint symptoms in individuals with and without limb length inequality.
Hazard of incident and progressive knee and hip radiographic osteoarthritis and chronic joint symptoms in individuals with and without limb length inequality.
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DOI：
10.3899/jrheum.091410
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Jordan JM
中科院分区：
文献类型：
--
作者：
Golightly YM;Allen KD;Helmick CG;Schwartz TA;Renner JB;Jordan JM
Examine the hazard of incident and progressive radiographic OA (rOA) and chronic joint symptoms at the hip and knee by limb length inequality (LLI) in a large, community-based sample. A longitudinal cohort completed baseline (1991–1997) clinical evaluation and identical follow-up assessment (1999–2003) (median follow-up time = 5.9 years, range=3.0–13.1 years). LLI was defined at baseline as a measured difference between limbs of ≥ 2 cm. The study groups with LLI data comprised 1,583 participants with paired (baseline and follow-up) knee radiographs and 1,453 participants with paired hip radiographs. Multivariable Cox regression models were used to examine the hazard of incident and progressive knee and hip rOA and chronic joint symptoms, while adjusting for demographic and clinical factors. The hazard of developing incident knee or hip rOA was 20–30% higher and of developing progressive knee or hip rOA was 35–83% higher among participants with LLI, but results were only statistically significant for progressive knee rOA (adjusted hazard ratio = 1.83, 95% confidence interval = 1.10–3.05). The hazards of progressive chronic knee symptoms and incident and progressive chronic hip symptoms were 13–59% higher among participants with LLI, but were not statistically significant. LLI was associated with progressive knee rOA and was non-significantly associated with incident knee or hip rOA and progressive hip rOA, progressive chronic knee symptoms, and incident and progressive chronic hip symptoms. Longer studies may strengthen these associations and help determine whether LLI is a risk factor or marker of these outcomes.
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影响因子：
39.2
作者：
Harvey WF;Yang M;Cooke TD;Segal NA;Lane N;Lewis CE;Felson DT
通讯作者：
Felson DT
影响因子：
--
作者：
Cerejo, R;Dunlop, DD;Sharma, L
通讯作者：
Sharma, L
影响因子：
7
作者：
Golightly, Y. M.;Allen, K. D.;Jordan, J. M.
通讯作者：
Jordan, J. M.
影响因子：
4.7
作者：
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通讯作者：
Fryer, JG
影响因子：
4.7
作者：
deBock, GH;Kaptein, AA;Mulder, JD
通讯作者：
Mulder, JD