Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.
Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.
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DOI：
10.1155/2012/823902
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发表时间：
2012
影响因子：
4.6
通讯作者：
Choi DK
中科院分区：
文献类型：
--
作者：
Koppula S;Kumar H;Kim IS;Choi DK
活性氧（Reactive oxygen species, ROSs）在帕金森病（PD）等神经退行性疾病的病因学研究中扮演着重要角色。在几种ros生成系统中，炎症酶烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶和诱导型一氧化氮合酶（iNOS）被认为起主要作用。越来越多的证据表明，NADPH氧化酶的激活和iNOS的表达与高活性ROS的产生直接相关，ROS影响多种细胞成分，并优先损害PD中脑多巴胺能神经元。因此，适当管理或抑制这些酶产生的ROS可能是减少PD中神经元变性的治疗靶点。在这里，我们总结了最近开发的药物和专利声称的抑制剂NADPH氧化酶和iNOS酶在PD的实验模型。
Reactive oxygen species (ROSs) are emerging as important players in the etiology of neurodegenerative disorders including Parkinson's disease (PD). Out of several ROS-generating systems, the inflammatory enzymes nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and inducible nitric oxide synthase (iNOS) were believed to play major roles. Mounting evidence suggests that activation of NADPH oxidase and the expression of iNOS are directly linked to the generation of highly reactive ROS which affects various cellular components and preferentially damage midbrain dopaminergic neurons in PD. Therefore, appropriate management or inhibition of ROS generated by these enzymes may represent a therapeutic target to reduce neuronal degeneration seen in PD. Here, we have summarized recently developed agents and patents claimed as inhibitors of NADPH oxidase and iNOS enzymes in experimental models of PD.
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影响因子：
4.7
作者：
Condello, Salvatore;Curro, Monica;Ientile, Riccardo
通讯作者：
Ientile, Riccardo
影响因子：
4.7
作者：
Choi, SH;Lee, DY;Jin, BK
通讯作者：
Jin, BK
DOI：
10.1111/j.1749-6632.1994.tb19825.x
发表时间：
1994-01-01
期刊：
MODELS OF NEUROPEPTIDE ACTION
影响因子：
--
作者：
ARIMURA, A;SOMOGYVARIVIGH, A;BRENNEMAN, DE
通讯作者：
BRENNEMAN, DE
影响因子：
5.3
作者：
Choi, DK;Pennathur, S;Przedborski, S
通讯作者：
Przedborski, S
影响因子：
8.3
作者：
Cockroft, KM;Meistrell, M;Tracey, KJ
通讯作者：
Tracey, KJ