Influence of b2 adrenergic receptor polymorphism (rs1042713 and rs1042714) on anthropometric, hormonal and lipid profiles in polycystic ovarian syndrome.
Influence of b2 adrenergic receptor polymorphism (rs1042713 and rs1042714) on anthropometric, hormonal and lipid profiles in polycystic ovarian syndrome.
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B2肾上腺素能受体多态性（RS1042713和RS1042714）对多囊卵巢综合征中人体测量，激素和脂质谱的影响。
DOI：
10.5937/jomb0-26183
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发表时间：
2021-01-26
影响因子：
2.5
通讯作者：
Warsy A
中科院分区：
文献类型：
--
作者：
Daghestani MH;Omair M;Daghestani M;Abdel-Razeq SS;Kaya N;Warsy A
多囊卵巢综合征（PCOS）是一种经常遇到的疾病。这项研究旨在鉴定沙特PCOS发育中ADRB2中的多态性，并研究其对脂质，激素和人体测量学参数的影响。
研究了患有PCOS和健康对照的沙特女性（100）（100）。估计胆固醇，甘油三酸酯，高密度脂蛋白（HDL-C），低密度脂蛋白（LDL-C），血浆葡萄糖，瘦素胰岛素和生长素蛋白的估计。提取DNA，并将带外显子1的ADRB2片段放大并测序。
与正常体重组相比，肥胖PCOS的腰围，脂质，脂质，葡萄糖和胰岛素的腰围，脂质，葡萄糖和胰岛素明显更高。瘦素和生长素蛋白没有差异。鉴定了两个单一核苷酸多态性（SNP）：RS1042713（arg16gly; a> g）和RS1042714（GLN27GLU; C> g）。 RS1042713的基因型和等位基因频率在总PCOS和正常重量上没有差异，肥胖的PCOS与对照组相比。但是，RS1042714与PCOS的开发显着相关，在PCOS的开发中，较小的G等位基因可抵抗PCOS的开发。
ADRB的RS1042714多态性与沙特的PCOS开发相关，而RS1042713则没有。但是，RS1042713的GG基因型与BMI，腰围，臀部，W/H和瘦素的升高以及降低的生长素蛋白显着相关。另一方面，RS1042714基因型除非纯合GG具有较高的甘油三酸酯和较低的HDL-C，均未与任何异常相关。有趣的是，葡萄糖在携带两个研究的SNP的不同基因型的个体中显示出不同的相关模式，这清楚地表明，对正常养分的代谢反应受ADRB2中SNP的基因型的显着影响。
Polycystic ovarian syndrome (PCOS) is a frequently encountered disorder. This study aimed to identify polymorphisms in ADRB2 in Saudi PCOS development and to study its influence on lipids, hormones, and anthropometric parameters. Saudi females (100) suffering from PCOS and healthy controls (100) were investigated. The estimation of cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), plasma glucose, leptin Insulin, and ghrelin were carried out. The DNA was extracted, and ADRB2 fragment carrying the exon 1 was amplified and sequenced. The waist, W/H ratio, lipids, glucose, and insulin were significantly higher in the obese PCOS compared to the normal weight group. The leptin and ghrelin were not different. Two single nucleotide polymorphisms (SNPs): rs1042713 (Arg16Gly; A>G) and rs1042714 (Gln27Glu; C>G) were identified. The genotype and allele frequency of rs1042713 did not differ in the total PCOS and normal weight, and obese PCOS compare to the controls. However, rs1042714 was significantly associated with PCOS development, where the minor G allele was protective against PCOS development. The rs1042714 polymorphism of the ADRB associates with PCOS development in Saudis, while rs1042713 does not. However, the GG genotype of rs1042713 associates significantly with elevated BMI, waist, hip, W/H, and leptin, and decreased ghrelin. On the other hand, rs1042714 genotypes do not associate with any abnormality except the homozygous GG have higher triglycerides and lower HDL-C. Interestingly, glucose showed different correlation patterns in individuals carrying different genotypes of the two studied SNP, indicating clearly that the metabolic responses to a normal nutrient are significantly influenced by the genotypes of the SNPs in ADRB2.
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影响因子：
6.1
作者：
Kim, Jin Ju;Choi, Young Min;Moon, Shin Yong
通讯作者：
Moon, Shin Yong
影响因子：
3.2
作者：
Masuo, K;Katsuya, T;Tuck, ML
通讯作者：
Tuck, ML
影响因子：
4.5
作者：
Daghestani, Maha H.;Warsy, Arjumand;Al-zhrani, Sabah
通讯作者：
Al-zhrani, Sabah
影响因子：
5.8
作者：
Palmert, MR;Gordon, CM;Dunaif, A
通讯作者：
Dunaif, A
影响因子：
37.8
作者：
Masuo, K;Katsuya, T;Tuck, ML
通讯作者：
Tuck, ML