Self-Sorting and Coassembly of Fluorinated, Hydrogenated, and Hybrid Janus Dendrimers into Dendrimersomes.
Self-Sorting and Coassembly of Fluorinated, Hydrogenated, and Hybrid Janus Dendrimers into Dendrimersomes.
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DOI：
10.1021/jacs.6b08069
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发表时间：
2016-09-28
影响因子：
15
通讯作者：
Percec V
中科院分区：
文献类型：
--
作者：
Xiao Q;Rubien JD;Wang Z;Reed EH;Hammer DA;Sahoo D;Heiney PA;Yadavalli SS;Goulian M;Wilner SE;Baumgart T;Vinogradov SA;Klein ML;Percec V
The modular synthesis of a library containing seven self-assembling amphiphilic Janus dendrimers is reported. Three of these molecules contain environmentally friendly chiral-racemic fluorinated dendrons in their hydrophobic part (RF), one contains achiral hydrogenated dendrons (RH), while one denoted hybrid Janus dendrimer, contains a combination of chiral-racemic fluorinated and achiral hydrogenated dendrons (RHF) in its hydrophobic part. Two Janus dendrimers contain either chiral-racemic fluorinated dendrons and a green fluorescent dye conjugated to its hydrophilic part (RF-NBD) or achiral hydrogenated and a red fluorescent dye in its hydrophilic part (RH-RhB). These RF, RH, and RHF Janus dendrimers self-assembled into unilamellar or onion-like soft vesicular dendrimersomes (DSs), with similar thicknesses to biological membranes by simple injection from ethanol solution into water or buffer. Since RF and RH dendrons are not miscible, RF-NBD and RH-RhB were employed to investigate by fluorescence microscopy the self-sorting and co-assembly of RF and RH as well as of phospholipids into hybrid DSs mediated by the hybrid hydrogenated-fluorinated RHF Janus dendrimer. The hybrid RHF Janus dendrimer co-assembled with both RF and RH. Three-component hybrid DSs containing RH, RF, and RHF were formed when the proportion of RHF was higher than 40%. With low concentration of RHF and in its absence, RH and RF self-sorted into individual RH or RF DSs. Phospholipids were also co-assembled with hybrid RHF Janus dendrimers. The simple synthesis and self-assembly of DSs and hybrid DSs, their similar thickness with biological membranes and their imaging by fluorescence and 19F-MRI make them important tools for synthetic biology.
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影响因子：
6.2
作者：
Du, Wenjun;Nystrom, Andreas M.;Zhang, Lei;Powell, Kenya T.;Li, Yali;Cheng, Chong;Wickline, Samuel A.;Wooley, Karen L.
通讯作者：
Wooley, Karen L.
影响因子：
1.6
作者：
ISHIKAWA, Y;KUWAHARA, H;KUNITAKE, T
通讯作者：
KUNITAKE, T
影响因子：
56.9
作者：
Discher, BM;Won, YY;Hammer, DA
通讯作者：
Hammer, DA
影响因子：
56.9
作者：
Percec, Virgil;Wilson, Daniela A.;Ropponen, Jarmo
通讯作者：
Ropponen, Jarmo
影响因子：
6.7
作者：
Filippi, M.;Patrucco, D.;Terreno, E.
通讯作者：
Terreno, E.