Are arterial, muscle and working limb lactate exchange data obtained on men at altitude consistent with the hypothesis of an intracellular lactate shuttle?
Are arterial, muscle and working limb lactate exchange data obtained on men at altitude consistent with the hypothesis of an intracellular lactate shuttle?
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在高海拔地区获得的男性动脉、肌肉和工作肢体乳酸交换数据是否与细胞内乳酸穿梭的假设一致？
DOI：
10.1007/978-1-4615-4711-2_16
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发表时间：
1999
影响因子：
--
通讯作者：
Brooks,GA
中科院分区：
文献类型：
--
作者：
Brooks,GA
The “Lactate Shuttle” Hypothesis posits that lactate removal requires exchange among producing and consuming cells. The “Intra-cellular Lactate Shuttle” hypothesis posits that lactate exchange occurs among compartments within cells, and that mitochondria are the major sites of cellular lactate disposal. Thus, cells with high mitochondrial densities (cardiocytes, myocytes, hepatocytes) are those which participate in lactate clearance. The model of an Intracellular Lactate Shuttle recognizes that the Keqfor LDH is 3.6 × 104M-1; thus, glycolysis results in cytosolic lactate production regardless of the intracellular PO2. The model also requires presence of a mitochondrial monocarboxylate transporter (MCT) that allows uptake of lactate as well as pyruvate, and intra-mitochondrial LDH whose function is linked to the ETC, and which permits lactate→pyruvate conversion and oxidation. Recently, we have shown that liver, heart and muscle mitochondria readily oxidize lactate and contain LDH and MCT1. Accordingly, we have concluded that lactate is the predominant monocarboxylate oxidized by mitochondriain vivo. The model of an “Intra-cellular Lactate Shuttle” is consistent with many of the observations on men at sea level and altitude. The observations include: oxidation is the primary fate of lactate disposal during rest and exercise; lactate production and oxidation occur simultaneously within resting and working muscle; increasing [lactate]aincreases muscle lactate extraction, and that by increasing SaO2acclimatization reduces blood [lactate].
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DOI：
10.1152/ajpendo.1995.269.3.e409
发表时间：
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期刊：
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影响因子：
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