Suboptimal effectiveness of the 2011-2012 seasonal influenza vaccine in adult Korean populations.
Suboptimal effectiveness of the 2011-2012 seasonal influenza vaccine in adult Korean populations.
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DOI：
10.1371/journal.pone.0098716
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kim WJ
中科院分区：
文献类型：
--
作者：
Choi WS;Noh JY;Baek JH;Seo YB;Lee J;Song JY;Park DW;Lee JS;Cheong HJ;Kim WJ
在韩国成年人群中评估了 2011-2012 年季节性流感疫苗的有效性，了解其预防实验室确诊的流感和流感相关并发症的效果。对 2011 年 9 月至 2012 年 5 月期间访问四家选定医院的患者进行了回顾性病例对照和回顾性队列研究。该分析包括 1,130 名实验室确诊的流感患者。对于每个流感病例，以1:1的比例选择一名对照患者。对照被定义为年龄组匹配的患者，在症状出现 48 小时内因流感样疾病到同一家医院就诊，但实验室检查结果为流感阴性。病例和对照之间的年龄组和就诊日期相匹配。疫苗有效性 (VE) 定义为 [100 ×（接种疫苗者与未接种疫苗者的流感 1 优势比）]。通过查看病历和进行电话访谈，对实验室确诊的流感患者进行至少一个月的随访。 2011-2012 年季节性流感疫苗预防实验室确诊流感的 VE 为 3.8% [95% CI，-16.5% 至 20.6%]，甲型流感为 -16.1%（95% CI，-48.3 至 9.1），乙型流感为 26.2%（95% CI，-2.6 至 46.2）。 19至49岁参与者的VE为0.3%（95% CI，-29.4至23.1），50至64岁参与者的VE为11.9%（95% CI，-34.3至42.2），≥65岁参与者的VE为-3.9%（-60.1至32.5）。预防任何流感相关并发症的调整后 VE 为 -10.7%（95% CI，-41.1% 至 42.2%）。 2011-2012 年季节性流感疫苗未能有效预防韩国成年人群中实验室确诊的流感或流感相关并发症。
The effectiveness of the 2011–2012 seasonal influenza vaccine was evaluated in adult Korean populations with regard to how well it could prevent laboratory-confirmed influenza and influenza-related complications. A retrospective case-control and retrospective cohort study was conducted among patients who visited four selected hospitals from September 2011 to May 2012. The analysis included 1,130 laboratory-confirmed influenza patients. For each influenza case, one control patient was chosen at a ratio of 1:1. A control was defined as an age group-matched patient who visited the same hospital with influenza-like illness within 48 hours of symptom onset but for whom laboratory tests were negative for influenza. Age group and visit date were matched between the cases and controls. Vaccine effectiveness (VE) was defined as [100 × (1-odds ratio for influenza in vaccinated versus non-vaccinated persons)]. The patients with laboratory-confirmed influenza were followed for at least one month through reviewing the medical records and conducting a telephone interview. The VE of the 2011–2012 seasonal influenza vaccine was 3.8% [95% confidence interval (CI), -16.5% to 20.6%] for preventing laboratory-confirmed influenza, -16.1% (95% CI, -48.3 to 9.1) for influenza A and 26.2% (95% CI, -2.6 to 46.2) for influenza B. The age-specific adjusted VE was 0.3% (95% CI, -29.4 to 23.1) among participants aged 19 to 49 years, 11.9% (95% CI, -34.3 to 42.2) among those aged 50 to 64 years and -3.9% (-60.1 to 32.5) among those aged ≥65 years. The adjusted VE for preventing any influenza-related complications was -10.7% (95% CI, -41.1% to 42.2%). The 2011–2012 seasonal influenza vaccine was not effective in preventing laboratory-confirmed influenza or influenza-related complications in adult Korean populations.
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