Cigarette smoking, alcohol intake, and thyroid cancer risk: a pooled analysis of five prospective studies in the United States.
Cigarette smoking, alcohol intake, and thyroid cancer risk: a pooled analysis of five prospective studies in the United States.
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DOI：
10.1007/s10552-012-0039-2
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发表时间：
2012-10
影响因子：
2.3
通讯作者：
de Gonzalez, Amy Berrington
中科院分区：
文献类型：
--
作者：
Kitahara, Cari M.;Linet, Martha S.;Freeman, Laura E. Beane;Check, David P.;Church, Timothy R.;Park, Yikyung;Purdue, Mark P.;Schairer, Catherine;de Gonzalez, Amy Berrington
我们通过对五项前瞻性研究的汇总分析，研究了吸烟、饮酒和甲状腺癌风险之间的关系。来自美国五项前瞻性研究的数据被标准化，然后合并成一个汇总数据集（384,433名男性和361,664名女性）。甲状腺癌的合并风险比（HR）和95%置信区间（CI）是根据吸烟和饮酒的相互调整模型估计的，并根据年龄、性别、教育程度、种族、婚姻状况、体重指数和队列进行了额外调整。在随访期间，确定了1003例甲状腺癌病例（335例男性和668例女性）。与从不吸烟者相比，目前吸烟与甲状腺癌风险降低相关（HR=0.68, 95% CI:0.55-0.85）；这种关联在不饮酒者中稍强（HR=0.46, 95% CI:0.29-0.74）。与从不吸烟者相比，戒烟者的风险没有降低。更大的吸烟强度、持续时间和包年与前吸烟者和现吸烟者的风险进一步降低有关。酒精摄入量也与甲状腺癌风险呈负相关（≥7杯/周vs 0， HR=0.72, 95% CI:0.58-0.90， p趋势=0.002）。在乳头状肿瘤和滤泡性肿瘤中，吸烟和酒精的负相关更为明显。这项综合分析的结果表明，吸烟和饮酒都与甲状腺乳头状癌（可能还有甲状腺滤泡癌）的风险降低有关。
We examined the associations between cigarette smoking, alcohol intake, and thyroid cancer risk in a pooled analysis of five prospective studies. Data from five prospective U.S. studies were standardized and then combined into one aggregate dataset (384,433 men and 361,664 women). Pooled hazard ratios (HR) and 95% confidence intervals (CI) for thyroid cancer were estimated from mutually-adjusted models of cigarette smoking and alcohol intake, which were additionally adjusted for age, sex, education, race, marital status, body mass index, and cohort. Over follow-up, 1,003 incident thyroid cancer cases (335 men and 668 women) were identified. Compared to never smokers, current smoking was associated with reduced risk of thyroid cancer (HR=0.68, 95% CI:0.55-0.85); this association was slightly stronger among non-drinkers (HR=0.46, 95% CI:0.29-0.74). No reduction in risk was observed for former, compared to never, smokers. Greater smoking intensity, duration, and pack-years were associated with further reductions in risk among former and current smokers. Alcohol intake was also inversely associated with thyroid cancer risk (≥7 drinks/week versus 0, HR=0.72, 95% CI:0.58-0.90, P-trend=0.002). Inverse associations with smoking and alcohol were more pronounced for papillary versus follicular tumors. The results of this pooled analysis suggest that both cigarette smoking and alcohol consumption are associated with reduced risks of papillary thyroid cancer and, possibly, follicular thyroid cancer.
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影响因子：
7
作者：
Huedo-Medina, Tania B.;Sanchez-Meca, Julio;Botella, Juan
通讯作者：
Botella, Juan
影响因子：
4.7
作者：
Nagano J;Mabuchi K;Yoshimoto Y;Hayashi Y;Tsuda N;Land C;Kodama K
通讯作者：
Kodama K
DOI：
10.1158/1055-9965.epi-08-0960
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Enewold L;Zhu K;Ron E;Marrogi AJ;Stojadinovic A;Peoples GE;Devesa SS
通讯作者：
Devesa SS
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
DOI：
10.1158/1055-9965.epi-10-1220
发表时间：
2011-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kitahara CM;Platz EA;Freeman LE;Hsing AW;Linet MS;Park Y;Schairer C;Schatzkin A;Shikany JM;Berrington de González A
通讯作者：
Berrington de González A