Echocardiographic speckle tracking radial strain imaging to assess ventricular dyssynchrony in a pacing model of resynchronization therapy.
Echocardiographic speckle tracking radial strain imaging to assess ventricular dyssynchrony in a pacing model of resynchronization therapy.
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DOI：
10.1016/j.echo.2008.09.012
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发表时间：
2008-12
影响因子：
6.5
通讯作者：
Gorcsan, John, III
中科院分区：
文献类型：
--
作者：
Tanabe, Masaki;Lamia, Bouchra;Tanaka, Hidekazu;Schwartzman, David;Pinsky, Michael R.;Gorcsan, John, III
斑点追踪成像是一种很有前途的新的超声心动图方法，以评估左心室（LV）的机械不同步。我们的目的是通过在左束支分支传导阻滞（LBBB）和心脏起搏治疗（CRT）的动物模型中与角度校正组织多普勒（TD）进行比较，评估一种新的斑点跟踪局部应变算法。10只开胸犬行常规左心室中段短轴平面灰阶和组织多普勒成像。通过从右心室（RV）、LV游离壁和双心室部位起搏来改变电激活，以产生不同程度的机械不同步并改变局部功能。在同一数字电影回放上，通过角度校正TD、TD M模式和散斑跟踪测量节段性峰值应变时间、峰值应变和逐帧应变。在240个可能配对的组织多普勒和斑点追踪节段中，222个节段（93%）的数据可用;前瞻性排除了具有导管伪影的图像。每种方法的总应变达峰时间比较相关性良好：r = 0.96，偏差=-6 ± 20 ms。在80个可能配对的M模式组织多普勒和斑点跟踪段中，76个段（95%）的应变数据可用。每种方法在1012帧中进行的总体峰值应变时间、峰值应变和逐帧应变分析的比较相关性良好：分别为r=0.98，偏倚1± 14 ms; r=0.82，偏倚3±7%; r=0.91，偏倚0±6%。在不同步的动物模型中，使用超声心动图斑点跟踪的局部应变分析径向应变与角度校正组织多普勒成像的应变密切相关。散斑跟踪径向应变具有潜在的临床应用价值。
Speckle tracking imaging is a promising new echocardiographic method to assess left ventricular (LV) mechanical dyssynchrony. Our aim was to assess a new speckle tracking regional strain algorithm by comparison to angle corrected tissue Doppler (TD) in an animal model of left bundle branch block (LBBB) and cardiac resynchronization therapy (CRT). Ten open chest dogs had routine grayscale and tissue Doppler images of the mid-left ventricular (LV) short-axis plane. Electrical activation was altered by pacing from right ventricular (RV), LV free wall, and biventricular sites to create various degree of mechanical dyssynchrony and alter regional function. Segmental time-to-peak strain, peak strain and frame-by-frame strain were measured by angle corrected TD, TD M-mode and by speckle tracking on the same digital cineloop. Of 240 possible paired tissue Doppler and speckle tracking segments, data were available for 222 segments (93%); images with catheter artifacts were prospectively excluded. Comparative overall time-to-peak strain by each method correlated well: r = 0.96, bias=−6 ± 20 ms. Of 80 possible paired M-mode tissue Doppler and speckle tracking segments, strain data were available for 76 segments (95%). Comparative overall time-to-peak strain, peak strain and frame-by-frame strain analysis in 1012 frames by each method correlated well: r=0.98, bias of 1±14ms; r=0.82, bias of 3±7%; and r=0.91, bias of 0±6% respectively. Regional strain analysis using echocardiographic speckle tracking radial strain strongly correlated with strain by angle-corrected tissue Doppler imaging in an animal model of dyssynchrony. Speckle tracking radial strain has potential for clinical applications.
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