Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis.
Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis.
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EGFR与CXCR4、CCR7趋化因子受体预测乳腺癌转移及预后的相关作用
DOI：
10.1186/1756-9966-29-16
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发表时间：
2010-02-24
期刊：
影响因子：
--
通讯作者：
Sun B
中科院分区：
文献类型：
--
作者：
Liu Y;Ji R;Li J;Gu Q;Zhao X;Sun T;Wang J;Li J;Du Q;Sun B
趋化因子受体CXCR4和CCR7在肿瘤侵袭转移过程中发挥重要作用。本研究通过研究CXCR4、CCR7、CXCL12、CCL21和EGFR的表达来阐明这些生物标志物在乳腺癌转移和预后中的作用。方法采用免疫组化方法对200例原发性乳腺癌组织芯片（TMA）标本中CXCR4、CCR7、CXCL12、CCL21、EGFR及ER、PR、HER-2/neu等生物标志物进行分析。同样的方法也检查了同一患者的相应淋巴结。结果CXCR4和CCR7及其配体CXCL12和CCL21在淋巴结转移的肿瘤细胞中显著高表达。同样，EGFR在淋巴结转移的肿瘤中也高表达。这些配体在转移性肿瘤中的表达比在同一患者的原发肿瘤中的表达更明显。此外，CXCR4伴CCR7和CXCL12伴CCL21的表达均上调。Kaplan-Meier生存分析显示，CXCR4、CCR7和EGFR高表达患者的生存期较低表达患者短。结论CXCR4、CCR7和EGFR的表达可能与淋巴结转移有关。此外，这些受体的表达可以作为乳腺癌患者预后不良的一个指标。
BackgroundThe chemokine receptors CXCR4 and CCR7 play an important role in cancer invasion and metastasis. This study investigated the expression of CXCR4, CCR7, CXCL12, CCL21, and EGFR to illustrate the role of these biomarkers in breast cancer metastasis and prognosis.MethodsThe CXCR4, CCR7, CXCL12, CCL21, and EGFR biomarkers were analyzed along with ER, PR, and HER-2/neu in breast cancer tissue microarray (TMA) specimens, including 200 primary breast cancer specimens by immunohistochemistry. Corresponding lymph nodes from the same patients were also examined using the same method.ResultsTogether with their CXCL12 and CCL21 ligands, CXCR4 and CCR7 were significantly highly expressed in tumor cells with lymph node (LN) metastasis. Similarly, EGFR was expressed highly in tumors with LN metastasis. The ligands were especially expressed in metastatic tumors than in primary tumors from the same patients. Moreover, the expression of both CXCR4 accompanied by CCR7 and CXCL12 accompanied by CCL21 were up-regulated. Kaplan-Meier survival analysis revealed that patients exhibiting high CXCR4, CCR7, and EGFR expression experienced a shorter survival period compared with those with low expression.ConclusionsThe expression of CXCR4, CCR7, and EGFR may be associated with LN metastasis. Moreover, the expression of these receptors can serve as an indicator of undesirable prognosis in patients with breast cancer.
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