A model of the feline medial gastrocnemius motoneuron-muscle system subjected to recurrent inhibition
A model of the feline medial gastrocnemius motoneuron-muscle system subjected to recurrent inhibition
复制标题
反复抑制的猫内侧腓肠肌运动神经元肌肉系统模型
DOI：
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发表时间：
2003
影响因子：
1.9
通讯作者：
U. Windhorst
中科院分区：
文献类型：
--
作者：
T. Uchiyama;H. Johansson;U. Windhorst
摘要：哺乳动物脊髓中的复发抑制是复杂的，其功能尚不清楚。骨架运动神经元(α-MN)通过再生的轴突侧支兴奋抑制性伦肖细胞(RCs)，进而抑制α-MN和其他神经元。递归抑制网络的解剖和功能结构是非均匀的，其增益和滤波特性受绕过α-MN的输入的调节。这一复杂的组织很可能在α-MN的离职和招募特性方面发挥重要作用。对这个系统进行建模是研究正常功能的假设角色的一种方式，包括肌肉疲劳和不同形式的生理性病理性震颤。本文提出了一个包括α-MNS、RCS和由α-MNS支配的肌纤维的详细模型。概述了模型背后的实验数据以及建模的原理和步骤。然后将RC模型的行为与文献中报道的实验数据进行了比较。对于不同数量的运动轴突单脉冲同步激活所产生的猝发响应，模型与实验数据吻合较好。此外，运动轴突激化率与RC放电率之间的静态关系在模型和实验中符合得很好，对于运动轴突率阶跃变化的动态反应也是如此。最终目的是使用这个模型来探索在疲劳和肌肉疼痛期间发生的正常和改变条件下，反复抑制在(等长)肌力的控制和稳定中的作用。
Abstract.Recurrent inhibition in the mammalian spinal cord is complex, and its functions are not yet well understood. Skeletomotoneurons (α-MNs) excite, via recurrent axon collaterals, inhibitory Renshaw cells (RCs), which in turn inhibit α-MNs and other neurons. The anatomical and functional structure of the recurrent inhibitory network is nonhomogeneous, and the gain and filtering characteristics of RCs are modulated by inputs circumventing α-MNs. This complex organization is likely to play important roles for the discharge and recruitment properties of α-MNs. Modeling this system is a way of investigating hypothesized roles for normal functioning including muscle fatigue and different forms of physiological pathological tremor. In this paper, a detailed model including α-MNs, RCs, and the muscle fibers innervated by the α-MNs is presented. Outlines of the experimental data underlying the model and the modeling philosophy and procedure are presented. Then the behavior of a RC model is compared with experimental data reported in the literature. Model and experimental data agree well for burst responses elicited by synchronous single-pulse activation of different numbers of motor axons. In addition, the static relation between motor-axon activation rate and RC firing rate agree fairly well in model and experiment, and the same applies to the dynamic responses to step changes in motor-axon rate. The ultimate objective is to use this model in probing the role of recurrent inhibition in the control and stability of (isometric) muscular force under normal and altered conditions occurring during fatigue and muscle pain.
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