Inhibitory effect of brain natriuretic peptide on central angiotensin II-stimulated pressor response in conscious rats

Inhibitory effect of brain natriuretic peptide on central angiotensin II-stimulated pressor response in conscious rats
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脑钠肽对清醒大鼠中枢血管紧张素II刺激的升压反应的抑制作用

DOI:
10.1016/0304-3940(88)90252-2
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发表时间:
1988
影响因子:
2.5
通讯作者:
H. Imura
H. Imura
中科院分区:
医学4区
文献类型:
--
作者:
G. Shirakami;K. Nakao;Takayuki Yamada;H. Itoh;K. Mori;K. Kangawa;N. Minamino;H. Matsuo;H. Imura

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本实验观察了脑室注射脑利钠肽(BNP)对清醒自由大鼠血压和心率的影响。脑室内(i.c.v.)注射BNP对基础血压和心率无影响,但可减弱I.C.V.血管紧张素II(AII)以剂量依赖的方式诱导升压反应。这些结果表明,BNP在中枢神经系统的血压调节中起作用。
The effect of intracerebroventricular injection of brain natriuretic peptide (BNP) on blood pressure and heart rate was studied in conscious, unrestrained rats. The intracerebroventricular (i.c.v.) injection of BNP did not affect basal blood pressure and heart rate, but it attenuated i.c.v. angiotensin II (AII)-induced pressor response in a dose-dependent manner. These results suggest that BNP plays a role in the regulation of blood pressure in the central nervous system.
大脑中的心房肽免疫反应性神经元:存在于心血管调节区域。
DOI: 10.1126/science.2858127
发表时间: 1985
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Saper,CB;Standaert,DG;Currie,MG;Schwartz,D;Geller,DM;Needleman,P
通讯作者: Needleman,P
大鼠下丘脑、心房和血浆中的心房钠尿因子:通过特异性放射免疫测定法测定。
DOI: 10.1016/0006-291x(84)91606-1
发表时间: 1984
影响因子: 3.1
作者:
Tanaka,I;Misono,KS;Inagami,T
通讯作者: Inagami,T