Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?
Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?
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DOI：
10.3389/fcvm.2021.792592
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发表时间：
2021
影响因子：
3.6
通讯作者：
Wan J
中科院分区：
文献类型：
--
作者：
Chen C;Yu LT;Cheng BR;Xu JL;Cai Y;Jin JL;Feng RL;Xie L;Qu XY;Li D;Liu J;Li Y;Cui XY;Lu JJ;Zhou K;Lin Q;Wan J
尽管心肌缺血/再灌注（I/R）损伤是导致大多数心肌细胞损伤和死亡的原因之一，但经皮冠状动脉介入治疗（PCI）是急性心肌梗死（AMI）最有效的再灌注策略之一。心肌I/R损伤的病理过程包括细胞凋亡、自噬以及钙超载、氧化应激和炎症引起的不可逆细胞死亡。最终，心肌 I/R 损伤会导致心肌细胞进一步损伤激增，从而导致最终梗死面积 (IS) 并导致心力衰竭住院以及接下来 12 个月内的全因死亡率。因此，添加辅助干预来改善心肌挽救和心功能需要进一步研究。植物化学物质是中草药中大量存在的非营养性生物活性次级化合物。人们在植物化学物质上投入了大量的精力，因为它们往往符合改善心肌缺血再灌注损伤而不影响临床疗效甚至产生协同作用的预期。我们总结了之前的工作，简要概述了心肌I/R损伤的机制，并重点探索了已研究的所有植物化学类型在心肌I/R损伤下的心脏保护作用和潜在机制。植物化学物质值得被用作对抗心肌缺血再灌注损伤的进一步开发和研究的有前景的治疗候选物。然而，还需要更多的研究来更好地了解使用植物化学物质治疗心肌缺血再灌注损伤的机制以及与该方法相关的可能的副作用。
Percutaneous coronary intervention (PCI) is one of the most effective reperfusion strategies for acute myocardial infarction (AMI) despite myocardial ischemia/reperfusion (I/R) injury, causing one of the causes of most cardiomyocyte injuries and deaths. The pathological processes of myocardial I/R injury include apoptosis, autophagy, and irreversible cell death caused by calcium overload, oxidative stress, and inflammation. Eventually, myocardial I/R injury causes a spike of further cardiomyocyte injury that contributes to final infarct size (IS) and bound with hospitalization of heart failure as well as all-cause mortality within the following 12 months. Therefore, the addition of adjuvant intervention to improve myocardial salvage and cardiac function calls for further investigation. Phytochemicals are non-nutritive bioactive secondary compounds abundantly found in Chinese herbal medicine. Great effort has been put into phytochemicals because they are often in line with the expectations to improve myocardial I/R injury without compromising the clinical efficacy or to even produce synergy. We summarized the previous efforts, briefly outlined the mechanism of myocardial I/R injury, and focused on exploring the cardioprotective effects and potential mechanisms of all phytochemical types that have been investigated under myocardial I/R injury. Phytochemicals deserve to be utilized as promising therapeutic candidates for further development and research on combating myocardial I/R injury. Nevertheless, more studies are needed to provide a better understanding of the mechanism of myocardial I/R injury treatment using phytochemicals and possible side effects associated with this approach.
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影响因子：
20.1
作者：
Calvert JW;Jha S;Gundewar S;Elrod JW;Ramachandran A;Pattillo CB;Kevil CG;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
3.4
作者：
Chen F;Li H;Zhu G;Chen X;Tang Z
通讯作者：
Tang Z
影响因子：
2.7
作者：
Chen, Lvyi;Lan, Zhou;Li, Ping
通讯作者：
Li, Ping
DOI：
10.1111/j.1742-7843.2007.00082.x
发表时间：
2007-08-01
影响因子：
3.1
作者：
Chen, Chang-Mu;Liu, Shing-Hwa;Lin-Shiau, Shoei-Yn
通讯作者：
Lin-Shiau, Shoei-Yn
DOI：
10.3736/jcim20111104
发表时间：
2011-11-01
期刊：
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
影响因子：
--
作者：
Chen, Yang;Huang, Jian-hua;Shen, Zi-yin
通讯作者：
Shen, Zi-yin