Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites
Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites
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Th9细胞和Th17细胞在恶性腹水发病机制中的作用
DOI：
10.1016/j.apjtb.2015.07.013
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发表时间：
2015-10
影响因子：
1.7
通讯作者：
Shan-Yu Qin
中科院分区：
文献类型：
--
作者：
Xian-Wen Yang;Hai-Xing Jiang;Xiao-Li Huang;Shi-Jia Ma;Shan-Yu Qin
目的探讨Th 9和Th 17细胞在恶性腹水（MA）中的作用。收集肝癌、肝硬化患者及30例健康人相应的外周血标本。流式细胞仪检测Th 9和Th 17细胞的频率。结果MA患者外周血Th 9、Th 17细胞比例及血清IL-9、IL-17水平均显著高于正常对照组和正常对照组（P< 0.05）。此外，在MA患者中，Th 9细胞与Th 17细胞以及IL-9呈正相关;然而，在哮喘患者或健康对照样品中未观察到这种正相关。Th 9和Th 17细胞在有淋巴结转移或远处转移的III、IV期MA患者中的比例明显高于无远处转移的I、II期MA患者（P< 0.05）。这项研究还表明，Th 9和Th 17细胞可能与IL-9的产生一起发挥其生物学功能。
ObjectiveTo assess the role of Th9 and Th17 cells in malignant ascites (MA).MethodsMA from 30 hepatic carcinoma patients and benign ascites from 30 cirrhotic patients were collected. Corresponding peripheral blood samples from these hepatic carcinoma and cirrhotic patients as well as 30 healthy subjects were collected. The frequency of Th9 and Th17 cells was tested by flow cytometry. Serum levels of interleukin (IL)-9 and IL-17 were examined by ELISA.ResultsThe observed frequency of Th9 and Th17 cells, and the IL-9 and IL-17 serum levels were significantly higher in MA patients than those in cirrhotic patients and healthy control samples (P< 0.05). Moreover, the Th9 cells demonstrated positive correlation with Th17 cells as well as IL-9 in MA patients; however, this positive correlation was not observed in the cirrhotic patients or healthy control samples. The frequency of Th9 and Th17 cells was distinctly higher in MA patients presenting with stage III or IV malignancy and with lymph node or distant metastasis than those in patients in stage I or II and without distant metastasis (P< 0.05).ConclusionsThe increased frequency of Th9 and Th17 cells in MA patients suggests that these two T cell subsets play a synergistic role in MA pathogenesis. This study also demonstrated that Th9 and Th17 cells may perform their biological functions in conjunction with IL-9 production.
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TYK-2在TH9和Th17细胞中的作用在过敏性哮喘中。
影响因子：
4.6
作者：
Übel C;Graser A;Koch S;Rieker RJ;Lehr HA;Müller M;Finotto S
通讯作者：
Finotto S
影响因子：
20.3
作者：
Kryczek, Ilona;Banerjee, Mousumi;Zou, Weiping
通讯作者：
Zou, Weiping
影响因子：
3.6
作者：
Peelen, E.;Damoiseaux, J.;Thewissen, M.
通讯作者：
Thewissen, M.
基里诺通过抑制Th1和Th17细胞的分化并诱导效应T细胞的凋亡来减轻实验性自身免疫性脑脊髓炎。
影响因子：
4.6
作者：
Xiao J;Yang R;Yang L;Fan X;Liu W;Deng W
通讯作者：
Deng W
DOI：
10.1084/jem.20130071
发表时间：
2013-12-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Turner JE;Morrison PJ;Wilhelm C;Wilson M;Ahlfors H;Renauld JC;Panzer U;Helmby H;Stockinger B
通讯作者：
Stockinger B