Mechanism of formation of concentrically laminated spherules: implication to Randall's plaque and stone formation.
Mechanism of formation of concentrically laminated spherules: implication to Randall's plaque and stone formation.
复制标题
DOI：
10.1007/s00240-008-0169-x
复制
发表时间：
2009-02
影响因子：
--
通讯作者：
Gower, Laurie B.
中科院分区：
文献类型：
--
作者：
Amos, Fairland F.;Dai, Lijun;Kumar, Rajendra;Khan, Saeed R.;Gower, Laurie B.
我们报告了通过聚合物诱导的液体前体（PILP）过程形成磷酸钙多层小球。在这种非经典结晶路线中，使用阴离子多肽添加剂促进液体状无定形磷酸钙（ACP）颗粒的沉淀，并且这些液滴聚结形成球状，随后结晶成球晶。在无定形球的结晶过程中，聚合物添加剂以及水合水在结晶前沿之前被排除，但一些聚合物被捕获在扩散限制区域内。这导致富含有机物的包裹体形成具有不同密度层的同心叠片。这些小球与兰德尔斑块和其他叠层宝石的晶体惊人的相似，表明这种生物结构也可能通过非晶态前体过程形成。鉴于泌尿道中存在富含有机物的环境，人们可能会预期在这种类型的凝固和转化过程中，大量有机材料会被截留在形成结石的分层区域内。
We report on the formation of calcium phosphate multi-laminated spherules via a polymer-induced liquid-like precursor (PILP) process. In this non-classical crystallization route, the precipitation of liquid-like amorphous calcium phosphate (ACP) particles is promoted using anionic polypeptide additives, and these droplets coalesce to form globules that later crystallize into spherulites. During crystallization of the amorphous globules, the polymer additive, as well as the waters of hydration, is excluded ahead of the crystallization front, but some polymer becomes entrapped within diffusion-limited zones. This results in the formation of concentric laminations with layers of variable density from organic-rich inclusions. The striking resemblance of these spherules with the crystals of the Randall’s plaque and other laminated stones suggests that such biological structures may form via an amorphous precursor process as well. Given the organic-rich environment present in the urinary tract, one might expect a large amount of organic materials to become entrapped within the stratified zones of a forming stone during this type of solidification and transformation process.
登录
查看更多内容
DOI：
10.1098/rspb.1997.0066
发表时间：
1997-03-22
影响因子：
4.7
作者：
Beniash, E;Aizenberg, J;Weiner, S
通讯作者：
Weiner, S
影响因子：
4.1
作者：
Crane, Nicole J.;Popescu, Victoria;Ignelzi, Michael A., Jr.
通讯作者：
Ignelzi, Michael A., Jr.
DOI：
10.1007/bf02279192
发表时间：
1968-01-01
期刊：
CALCIFIED TISSUE RESEARCH
影响因子：
--
作者：
EANES, ED;POSNER, AS
通讯作者：
POSNER, AS
影响因子：
62.1
作者：
Gower, Laurie B.
通讯作者：
Gower, Laurie B.
影响因子：
3.9
作者：
Amos, Fairland F.;Sharbaugh, Denise M.;Volkmer, Dirk
通讯作者：
Volkmer, Dirk