Aqueous extract of post-fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition.
Aqueous extract of post-fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition.
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后发酵茶水提取物通过调节脂肪生成基因表达和肝脂肪酸组成恢复高脂血症大鼠肝脏脂肪变性
DOI：
10.1186/1472-6882-14-263
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发表时间：
2014-07-23
影响因子：
--
通讯作者：
Wan X
中科院分区：
文献类型：
--
作者：
Zhou J;Zhang L;Zhang J;Wan X
BackgroundPost-fermented tea has been used for the prevention of metabolic syndrome in Western China. Present study reports the biochemical mechanism of lipid-lowering effects of Jing-wei fu tea (JWFT), a variety of post-fermented tea on high-fat diet-induced hyperglycemia and obesity in rats.MethodsAqueous extract of JWFT was prepared by putting them in boiling water, and then concentrated under reduced pressure. The major compounds of JWFT were determined by high performance liquid chromatography (HPLC). High-fat diet fed rats were orally administered different doses of JWFT aqueous extract (0.5, 1.0 and 2.0 g/kg) for four weeks. At the end of this experiment, hepatic lipids, serum leptin and lipids levels were determined using enzyme-linked immunosorbent assay (ELISA). The hepatic fatty acid composition was analyzed using gas chromatography mass (GC-MS). The relative expression of lipids metabolism genes was analyzed using reverse transcriptase-polymerase chain reaction (RT-PCR).ResultsThe results showed that JWFT inhibited the increase in the body weight, abdominal adipose weight, serum lipids and hepatic lipids, and decreased serum leptin levels of high-fat diet fed rats. JWFT normalized hepatic fatty acid composition of hyperlipidemia rats by up-regulating hepatic acetyl-CoA carboxylase (ACC), stearoyl-CoA desaturase 1 (SCD1) and fatty acid synthase (FAS) gene expression, and down-regulating carnitine palmitoyl transferase-1 (CPT1). Furthermore, the results showed that JWFT inhibited the absorption of lipids.ConclusionJWFT could mitigate the obesity-induced hepatic steatosis by regulating hepatic lipogenesis and lipolysis.
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影响因子：
7.1
作者：
Schwarz, JM;Linfoot, P;Aghajanian, K
通讯作者：
Aghajanian, K
影响因子：
4.1
作者：
Li, Qin;Liu, Zhonghua;Hu, Jiehui
通讯作者：
Hu, Jiehui
影响因子：
4.4
作者：
Kim, Hyun-Jin;Kim, Jin Hee;Yoon, Suk Hoo
通讯作者：
Yoon, Suk Hoo
8-C N-乙基-2-吡咯烷酮取代的黄烷-3-醇作为中国红茶在发酵后过程中形成的标记化合物，具有显着的抗氧化活性
影响因子：
8.8
作者：
Wang, Weinan;Zhang, Liang;Tu, Pengfei
通讯作者：
Tu, Pengfei
影响因子：
4.2
作者：
Wang, Shu;Noh, Sang K.;Koo, Sung I.
通讯作者：
Koo, Sung I.